Evidence map›Paper›PMID 33010225›Full record

ArticleThe American journal of medicine2021

Systolic Blood Pressure and Outcomes in Older Patients with HFpEF and Hypertension.

Charles Faselis, Phillip H Lam, Michael R Zile, Poonam Bhyan, Apostolos Tsimploulis, Cherinne Arundel, Samir Patel, Peter Kokkinos, Prakash Deedwania, Deepak L Bhatt and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. ANMCO position paper: diagnosis and treatment of heart failure with preserved systolic function.European heart journal supplements : journal of the European Society of Cardiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 1 country.

Charles FaselisVeterans Affairs Medical Center, Washington, DC; George Washington University, Washington, DC; Uniformed Services University, Washington, DC. Electronic address: charles.faselis@va.gov.
Phillip H LamVeterans Affairs Medical Center, Washington, DC; Georgetown University, Washington, DC; MedStar Washington Hospital Center, Washington, DC.
Michael R ZileMedical University of South Carolina, Charleston; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC.
Poonam BhyanCape Fear Valley Medical Center, Fayetteville, NC; Department of Epidemiology, Johns Hopkins University, Baltimore, Md.
Apostolos TsimploulisStony Brook University Hospital, Stony Brook, NY.
Cherinne ArundelVeterans Affairs Medical Center, Washington, DC; George Washington University, Washington, DC; Georgetown University, Washington, DC.
Samir PatelVeterans Affairs Medical Center, Washington, DC; George Washington University, Washington, DC.
Peter KokkinosVeterans Affairs Medical Center, Washington, DC; George Washington University, Washington, DC.
Prakash DeedwaniaVeterans Affairs Medical Center, Washington, DC; University of California, San Francisco.
Deepak L BhattBrigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Mass.
Qing Zeng-TrietlerVeterans Affairs Medical Center, Washington, DC; George Washington University, Washington, DC.
Charity J MorganVeterans Affairs Medical Center, Washington, DC; University of Alabama at Birmingham, Birmingham.
Wilbert S AronowNew York Medical College and Westchester Medical Center, Valhalla, NY.
Richard M AllmanGeorge Washington University, Washington, DC; University of Alabama at Birmingham, Birmingham.
Gregg C FonarowUniversity of California, Los Angeles.
Ali AhmedVeterans Affairs Medical Center, Washington, DC; George Washington University, Washington, DC; Georgetown University, Washington, DC. Electronic address: ali.ahmed@va.gov.
George Washington University · USGeorgetown University · USBrigham and Women's Hospital · USJohns Hopkins University · USMedical University of South Carolina · USMedStar Washington Hospital Center · USSan Francisco VA Medical Center · USStony Brook University Hospital · USUniformed Services University of the Health Sciences · USUniversity of California, Los Angeles · USVeterans Health Administration · USWestchester Medical Center · US

Funding

Comparative Effectiveness of Early Diagnostic and Disposition Strategies for Suspected Acute Coronary SyndromeR01HL134647 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SUN, BENJAMIN C · 2017 to 2020
$3.1M
Heart failure, chronic kidney disease, and renin-angiotensin system inhibitionR01HL085561 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHMED, ALI · 2006 to 2009
$1.5M
Neurohormonal Blockade and Outcomes in Diastolic Heart FailureR01HL097047 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHMED, ALI · 2009 to 2010
$915k
HSRD VA I01 HX002422NHLBI NIH HHS R01 HL085561NHLBI NIH HHS R01 HL097047NHLBI NIH HHS R01 HL134647
6 · The paper itself

Abstract

backgroundNew hypertension and heart failure guidelines recommend that systolic blood pressure (SBP) in patients with heart failure with preserved ejection fraction (HFpEF) and hypertension be lowered to <130 mm Hg.

methodsOf the 6778 hospitalized patients with HFpEF and a history of hypertension in the Medicare-linked OPTIMIZE-HF registry, 3111 had a discharge SBP <130 mm Hg. Using propensity scores for SBP <130 mm Hg, we assembled a matched cohort of 1979 pairs with SBP <130 versus ≥130 mm Hg, balanced on 66 baseline characteristics (mean age, 79 years; 69% women; 12% African American). We then assembled a second matched cohort of 1326 pairs with SBP <120 versus ≥130 mm Hg. Hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes associated with SBP <130 and <120 mm Hg were separately estimated in the matched cohorts using SBP ≥130 mm Hg as the reference.

resultsHRs (95% CIs) for 30-day, 12-month, and 6-year all-cause mortality associated with SBP <130 mm Hg were 1.20 (0.91-1.59; P = 0.200), 1.11 (0.99-1.26; P = 0.080), and 1.05 (0.98-1.14; P = 0.186), respectively. Respective HRs (95% CIs) associated with SBP <120 mm Hg were 1.68 (1.21-2.34; P = 0.002), 1.28 (1.11-1.48; P = 0.001), and 1.11 (1.02-1.22; P = 0.022). There was no association with readmission.

conclusionsAmong older patients with HFpEF and hypertension, compared with SBP ≥130 mm Hg, the new target SBP <130 mm Hg had no association with outcomes but SBP <120 mm Hg was associated with a higher risk of death but not of readmission. Future prospective studies need to evaluate optimal SBP treatment goals in these patients.

Indexed as

AgedAged, 80 and overBlood PressureCohort StudiesFemaleHeart FailureHumansHypertensionInpatientsMaleMedicareRegistriesTreatment OutcomeUnited StatesAll-cause mortalityHeart failure with preserved ejection fraction (HFpEF), ReadmissionSystolic blood pressure

Identifiers

PMID33010225
PMCPMC8941991
OpenAlexW3091453311

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.