Evidence map›Paper›PMID 33010224›Full record

ArticleImmunity2020

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.

Rachel Wong, Julia A Belk, Jennifer Govero, Jennifer L Uhrlaub, Dakota Reinartz, Haiyan Zhao, John M Errico, Lucas D'Souza, Tyler J Ripperger, Janko Nikolich-Zugich and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 132 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Extrafollicular and other non-germinal center B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  10. The multilayered identity of B cell memory.Cellular & molecular immunology · 2026
    Review
  11. Review
  12. iScience · 2025
    Article
  13. Article
  14. Orf virus-based vectors induce potent germinal center B cell, Tfh cell, and CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Rachel WongDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
Julia A BelkDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jennifer GoveroDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Jennifer L UhrlaubDepartment of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
Dakota ReinartzDepartment of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
Haiyan ZhaoDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
John M ErricoDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Lucas D'SouzaDepartment of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
Tyler J RippergerDepartment of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
Janko Nikolich-ZugichDepartment of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
Mark J ShlomchikDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Daved H FremontDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Michael S DiamondDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Deepta BhattacharyaDepartment of Immunobiology, University of Arizona, Tucson, AZ 85724, USA. Electronic address: deeptab@arizona.edu.
University of Arizona · USWashington University in St. Louis · USStanford University · USUniversity of Pittsburgh · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Maria Josefina Coloma · 2015 to 2026
$34.1M
Antibody-based Protection against FlavivirsesR01AI073755 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, FREMONT, DAVED H. · 2007 to 2022
$11.4M
Viral Discovery in Rheumatoid ArthritisP30AR048335 · NIAMS · WASHINGTON UNIVERSITY · PI WEIHL, CONRAD C · 2001 to 2015
$8.9M
An Advanced Vaccine Candidate To Prevent Zika Virus InfectionR01AI132186 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI SLIFKA, MARK K · 2017 to 2021
$6.9M
TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITYR01AI099108 · NIAID · WASHINGTON UNIVERSITY · PI Deepta Bhattacharya · 2012 to 2026
$6.4M
GLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGYR01AI129945 · NIAID · UNIVERSITY OF ARIZONA · PI Deepta Bhattacharya · 2018 to 2026
$4.8M
Human neutralizing antibodies for Zika virusR01AI127828 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2017 to 2021
$3.9M
Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training ProgramT32AG058503 · NIA · UNIVERSITY OF ARIZONA · PI Kristian Paul Doyle, JANKO Z. NIKOLICH · 2019 to 2026
$1.9M
Stanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2M
Single cell epigenomics in cancer immunity and immunotherapyK08CA230188 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2018 to 2020
$448k
NCI NIH HHS K08 CA230188NCI NIH HHS P30 CA023074NIAID NIH HHS P01 AI106695NIAID NIH HHS R01 AI073755NIAID NIH HHS R01 AI099108NIAID NIH HHS R01 AI127828NIAID NIH HHS R01 AI129945NIAID NIH HHS R01 AI132186NIAMS NIH HHS P30 AR048335NIA NIH HHS T32 AG058503NIGMS NIH HHS T32 GM120007Wellcome Trust
6 · The paper itself

Abstract

Memory B cells (MBCs) can respond to heterologous antigens either by molding new specificities through secondary germinal centers (GCs) or by selecting preexisting clones without further affinity maturation. To distinguish these mechanisms in flavivirus infections and immunizations, we studied recall responses to envelope protein domain III (DIII). Conditional deletion of activation-induced cytidine deaminase (AID) between heterologous challenges of West Nile, Japanese encephalitis, Zika, and dengue viruses did not affect recall responses. DIII-specific MBCs were contained mostly within the plasma-cell-biased CD80

Indexed as

Immunologic MemoryAnimalsB-LymphocytesCross ReactionsDisease Models, AnimalDose-Response Relationship, ImmunologicFlavivirusFlavivirus InfectionsHost-Pathogen InteractionsImmunizationMiceMice, KnockoutMice, TransgenicPlasma CellsSpecies SpecificityDengue virusflavirusesgerminal centerJapanese Encephalitis virusmemory B cellsplasma cellsWest Nile virusZika virus

Identifiers

PMID33010224
PMCPMC7677180
OpenAlexW3091009825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.