ArticleHuman brain mapping2020
Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- Association of prenatal depression and anxiety with cortical development and behavioral outcomes in 8-year-old children.Journal of affective disorders · 2026Article
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Timing of Exposure to Parental Depression From Pregnancy to Young Adulthood and Mental Health in Adult Offspring.JAMA network open · 2026Article
- Prenatal maternal psychological distress is associated with neurodevelopmental outcomes in toddlers with congenital heart disease.Pediatric research · 2026Article
- Prenatal experience of greater neighborhood disadvantage is associated with altered fetal volumetric brain growth in utero.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Prenatal antidepressant exposure is associated withFrontiers in neuroscience · 2026Article
- Obstetric complications, cortical gyrification, and cognition in first-episode psychosis.Psychological medicine · 2025Article
- Maternal depression during the perinatal period and its relationship with emotion regulation in young adulthood: An fMRI study in a prenatal birth cohort.Psychological medicine · 2025Article
- Immune Alterations in the Intrauterine Environment Shape Offspring Brain Development in a Sex-Specific Manner.Biological psychiatry · 2025Review
- Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.Molecular psychiatry · 2024Review
- Prenatal Maternal Psychological Distress During the COVID-19 Pandemic and Newborn Brain Development.JAMA network open · 2024Article
- Dentate Gyrus Microstructure Is Associated With Resilience After Exposure to Maternal Stress Across Two Human Cohorts.Biological psychiatry · 2024Article
- Association of Maternal Depression During Pregnancy and Recent Stress With Brain Age Among Adult Offspring.JAMA network open · 2023Article
- Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development.Frontiers in psychiatry · 2023Article
- Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- In search of sex-related mediators of affective illness.Biology of sex differences · 2021Review
- Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood.Human brain mapping · 2020Article
- Functional Connectivity to the Amygdala in the Neonate Is Impacted by the Maternal Anxiety Level During Pregnancy.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.