Evidence map›Paper›PMID 33010018›Full record

ReviewCellular and molecular neurobiology2022

Glioma Pericytes Promote Angiogenesis by Producing Periostin.

Sara Santos Bernardes, Mauro Cunha Xavier Pinto, Jaime Henrique Amorim, Vasco Ariston de Carvalho Azevedo, Rodrigo Ribeiro Resende, Akiva Mintz, Alexander Birbrair

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Sensory nerves in the spotlight of the stem cell niche.Stem cells translational medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sara Santos BernardesTissue Microenvironment Laboratory, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0000-0001-6700-2447
Mauro Cunha Xavier PintoLaboratory of Neuropharmacology and Neurochemistry, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.ORCID https://orcid.org/0000-0002-1680-8130
Jaime Henrique AmorimCenter of Biological Sciences and Health, Federal University of West Bahia, Barreiras, BA, Brazil.ORCID https://orcid.org/0000-0002-0623-2879
Vasco Ariston de Carvalho AzevedoCellular and Molecular Genetics Laboratory, Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-4775-2280
Rodrigo Ribeiro ResendeDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0000-0002-2003-0739
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0002-9905-3086
Alexander BirbrairTissue Microenvironment Laboratory, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. birbrair@icb.ufmg.br.ORCID https://orcid.org/0000-0003-1015-2561
Universidade Federal de Minas Gerais · BRColumbia University Irving Medical Center · USUniversidade Federal de Goiás · BRUniversidade Federal do Oeste da Bahia · BR

Funding

Sub-component for Institution # 16-01848 Novel moleculary targeted therapy of GBMP01CA207206 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEBINSKI, WALDEMAR · 2017 to 2021
$9.0M
Multi-receptor Targeting of GlioblastomaR01CA256285 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Waldemar Debinski · 2021 to 2026
$2.8M
Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
NCI NIH HHS 1R01CA179072-01A1NCI NIH HHS P01 CA207206NCI NIH HHS R01 CA179072NCI NIH HHS R01 CA256285
6 · The paper itself

Abstract

Glioma is the prevalent aggressive primary brain tumor, with a very poor prognosis. The absence of advanced understanding of the roles played by the cells within the glioma microenvironment limits the development of effective drugs. A recent study indicates that periostin expressed by pericytes is crucial for glioma angiogenesis. Here, we describe succinctly the results and implications of this discovery in what we know about pericytes within the glioma microenvironment. The emerging knowledge from this work will benefit the development of therapies for gliomas.

Indexed as

Brain NeoplasmsGliomaHumansMorphogenesisNeovascularization, PathologicPericytesTumor MicroenvironmentGliomaPericytesPeriostinTumor microenvironment

Identifiers

PMID33010018
PMCPMC8018985
OpenAlexW3090956497

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.