SynthesisNeurosurgical review2021
Comparing navigated transcranial magnetic stimulation mapping and "gold standard" direct cortical stimulation mapping in neurosurgery: a systematic review.
Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Metabolic Imaging as Future Technology and Innovation in Brain-Tumour Surgery: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review.Brain structure & function · 2023Pooled it
- Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.Neurosurgical review · 2022Pooled it
- Quantitative Navigated Transcranial Magnetic Stimulation Motor Mapping and nTMS-Guided Corticospinal Tractography in Healthy Individuals and Patients with Motor-Eloquent Brain Tumors.Brain sciences · 2026Article
- Determining hemispheric language dominance from MEG beta-power modulations: Concordance with fMRI.NeuroImage · 2026Article
- Contemporary surgical strategies for resection of intracranial gliomas.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Emerging paradigms in connectome-guided neurosurgery for central nervous system tumors: a narrative review of structural and functional connectomics.Annals of medicine and surgery (2012) · 2026Review
- Navigated Transcranial Magnetic Stimulation (nTMS): From Functional Brain Mapping to Clinical Applications in Neurosurgery and Neurology.Biomedicines · 2026Review
- Efficient Gaussian process-based motor hotspot hunting with concurrent optimization of TMS coil location and orientation.PLoS computational biology · 2026Article
- The onco-functional reorganization of language network underlying metaplasticity induced by gliomas.Frontiers in oncology · 2026Article
- Mills-Nithi algorithm for navigated transcranial magnetic stimulation motor mapping in healthy subjects and brain tumor patients.Clinical neurophysiology practice · 2026Article
- Preliminary Establishment of a Method and System for Detecting Neural Tumor Boundaries Based on Optical Coherence Tomography.MedComm · 2025Article
- Preoperative Brain Mapping Predicts Language Outcomes After Eloquent Tumor Resection.Human brain mapping · 2025Article
- Intraoperative integration of nTMS, CCEPs and DCS for language. A glance to the next future?Acta neurochirurgica · 2025Article
- The Role of Deep Cerebral Tracts in Predicting Postoperative Aphasia: An nTMS-Based Investigation of the Corticothalamic Fibers.Human brain mapping · 2025Article
- Preoperative and intraoperative neuromonitoring and mapping techniques impact oncological and functional outcomes in supratentorial function-eloquent brain tumours: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Efficient prospective electric field-informed localization of motor cortical targets of transcranial magnetic stimulation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional-guided frameless stereotactic biopsy of highly eloquent brain tumors.Brain & spine · 2025Article
- Staged intervention to enable the resection of a large left temporoinsular cystic glioblastoma with language preservation: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Scalp acupuncture guidance for identifying the optimal site for transcranial electrical stimulation of the hand.Experimental brain research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this systematic review is to create an overview of the literature on the comparison of navigated transcranial magnetic stimulation (nTMS) as a mapping tool to the current gold standard, which is (intraoperative) direct cortical stimulation (DCS) mapping. A search in the databases of PubMed, EMBASE, and Web of Science was performed. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and recommendations were used. Thirty-five publications were included in the review, describing a total of 552 patients. All studies concerned either mapping of motor or language function. No comparative data for nTMS and DCS for other neurological functions were found. For motor mapping, the distances between the cortical representation of the different muscle groups identified by nTMS and DCS varied between 2 and 16 mm. Regarding mapping of language function, solely an object naming task was performed in the comparative studies on nTMS and DCS. Sensitivity and specificity ranged from 10 to 100% and 13.3-98%, respectively, when nTMS language mapping was compared with DCS mapping. The positive predictive value (PPV) and negative predictive value (NPV) ranged from 17 to 75% and 57-100% respectively. The available evidence for nTMS as a mapping modality for motor and language function is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.