Evidence map›Paper›PMID 33009959›Full record

ArticleArchives of osteoporosis2020

Effect of increased serum 25(OH)D and calcium on structure and function of post-menopausal women: a pilot study.

H J Hillstrom, R Soeters, M Miranda, S I Backus, J Hafer, M Gibbons, I Thaqi, M Lenhoff, M T Hannan, Y Endo and 2 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of osteoporosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

H J HillstromLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA. HillstromH@HSS.edu.ORCID https://orcid.org/0000-0002-6440-1917
R SoetersLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
M MirandaLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
S I BackusLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
J HaferLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
M GibbonsLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
I ThaqiLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
M LenhoffLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
M T HannanInstitute for Aging Research, Hebrew SeniorLife, Harvard Medical School, 1200 Centre Street, Boston, MA, USA.
Y EndoLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
T SculcoLeon Root Motion Analysis Laboratory (LRMALab), Hospital for Special Surgery (HSS), 535 East 70th Street, New York, NY, USA.
J LaneMetabolic Bone Disease Service, HSS, 535 East 70th Street, New York, NY, USA.
Hospital for Special Surgery · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose was to determine if increasing serum 25(OH)D and calcium in postmenopausal women increased skeletal muscle size, strength, balance, and functional task performance while decreasing muscle fatigue. PCSA of the vastus lateralis increased and ascent of stairs time decreased after 6 months of increased serum 25(OH)D. PURPOSE: The Institute of Medicine recommends ≥ 20 ng/ml of serum 25-hydroxyvitamin D [25(OH)D] for bone and overall health. Serum 25(OH)D levels have been associated with physical performance, postural sway, and falls. The purpose of this study was to determine if increasing postmenopausal women's serum 25(OH)D levels from 20-30 ng/ml to 40-50 ng/ml improved skeletal muscle size, strength, balance, and functional performance while decreasing skeletal muscle fatigue.

methodsTwenty-six post-menopausal women (60-85 years old) with baseline serum 25(OH)D levels between 20 and 30 ng/ml were recruited. Oral over-the-counter (OTC) vitamin D3 and calcium citrate were prescribed to increase subjects' serum 25(OH)D to levels between 40 and 50 ng/ml, serum calcium levels above 9.2 mg/dl, and PTH levels below 60 pg/ml, which were confirmed at 6 and 12 weeks. Outcome measures assessed at baseline and 6 months included muscle physiological cross-sectional area (PCSA), muscle strength, postural balance, time to perform functional tasks, and muscle fatigue. Repeated measures comparisons between baseline and follow-up were performed.

resultsNineteen subjects completed the study. One individual could not afford the time commitment for the repeated measures. Three individuals did not take their vitamin D as recommended. Two subjects were lost to follow-up (lack of interest), and one did not achieve targeted serum 25(OH)D. Vastus lateralis PCSA increased (p = 0.007) and ascent of stair time decreased (p = 0.042) after 6 months of increasing serum 25(OH)D levels from 20-30 ng/ml to 40-50 ng/ml. Isometric strength was unchanged. Anterior-posterior center of pressure (COP) excursion and COP path length decreased (p < 0.1) albeit non-significantly, suggesting balance may improve from increased serum 25(OH)D and calcium citrate levels.

conclusionsSeveral measures of muscle structure and function were sensitive to elevated serum 25(OH)D and calcium levels indicating that further investigation of this phenomenon in post-menopausal women is warranted.

Indexed as

Absorptiometry, PhotonAgedAged, 80 and overBone Density Conservation AgentsCalciumCalcium CitrateCholecalciferolDose-Response Relationship, DrugFemaleHumansMiddle AgedMotor ActivityMuscle FatigueMuscle StrengthPilot ProjectsPostmenopause25-hydroxyvitamin DBone Density Conservation AgentsCalciumCalcium CitrateCholecalciferolVitamin DVitaminsFunctional task timesIsometric strengthMuscle cross-sectional areaMuscle fatiguePostural swayRecommended serum 25(OH)D levels

Identifiers

PMID33009959
PMCPMC7532965
OpenAlexW3090612429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.