ArticleBrain and behavior2020
White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Domain-specific cognitive function in euthymic bipolar disorder: a systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2024Pooled it
- State-Specific Segmental Abnormalities of White Matter Structure and Function in Pediatric Bipolar Disorders.Bipolar disorders · 2026Article
- White Matter Abnormalities in Bipolar II and Unipolar Depression - Evidence from Fixel-Based Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Identifying Physiological and Cognitive Indicators of Subthreshold Depression and Major Depressive Disorder Progression Risk.Neuropsychiatric disease and treatment · 2026Article
- Impact of immune function and white matter integrity on cognitive function in patients with bipolar disorder.Frontiers in immunology · 2026Article
- Distinguished Frontal White Matter Abnormalities Between Psychotic and Nonpsychotic Bipolar Disorders in a Pilot Study.Brain sciences · 2025Article
- Association Between White Matter Tract Integrity and Frontal-Executive Function in Non-Geriatric Adult Patients With Major Depressive Disorder.Psychiatry investigation · 2024Article
- Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression.Annals of translational medicine · 2022Article
- Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review.Journal of psychiatry and brain science · 2022Article
- Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Ensemble machine learning classification of daily living abilities among older people with HIV.EClinicalMedicine · 2021Article
- White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder.Brain and behavior · 2020Article
- Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders.Chronic stress (Thousand Oaks, Calif.)Article
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Authors and funding
11 authors.
Funding
Abstract
objectivesIn recent years, a growing number of diffusion tensor imaging (DTI) studies have compared white matter integrity between patients with major depressive disorder (MDD) and bipolar disorder (BD). However, few studies have examined the pathophysiological significance of different degrees of white matter abnormalities between the two disorders. The present study comprehensively assessed white matter integrity among healthy controls (HC) and euthymic patients with MDD and BD using whole-brain tractography and examined associations between white matter integrity and cognitive functioning.
methodsWe performed neurocognitive examinations and DTI with 30 HCs, 30 patients with MDD, and 30 patients with BD. We statistically evaluated white matter integrity and cognitive function differences across the three groups, assessing associations between white matter integrities and cognitive function.
resultsThe BD group showed lower fractional anisotropy (FA) for the corpus callosum body, as well as lower, sustained attention and set-shifting scores compared to the other groups. FA for the left body of the corpus callosum was correlated with sustained attention in patients with BD.
conclusionsThe significant reduction of white matter integrity in the corpus callosum in BD, compared to MDD, was associated with an impairment of sustained attention. This result promotes the understanding of the significance of white matter integrity in mood disorders.
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