Observational studyNeurocritical care2021
Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury: A Multicenter Observational Study.
Observational study in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Dynamic Variability of Sodium and Potassium Predicts Mortality in Critically Ill Patients With Ischemic Stroke: Evidence From Two Critical Care Cohorts.Brain and behavior · 2026Article
- Dynamic variability of serum sodium, potassium, and calcium and mortality after acute myocardial infarction: insights from traditional and machine learning approaches.BMC cardiovascular disorders · 2026Article
- Application of GHOST-CAP strategy combined with multimodal monitoring in the treatment of a patient with polytrauma complicated by severe traumatic brain injury: a case report.Frontiers in medicine · 2026Article
- Clinical outcomes associated with dynamic changes in serum sodium amongst adult patients with spontaneous subarachnoid hemorrhage and other critical illnesses: an exploratory scoping review.Critical care science · 2026Article
- Dynamic sodium dysregulation predicts mortality in intracerebral hemorrhage: A retrospective cohort study of temporal variability and absolute thresholds.Neurosurgical review · 2025Article
- Extracranial Effects of Traumatic Brain Injury: A Narrative Review.Clinics and practice · 2025Review
- The impact of serum sodium variability on surgical patients with aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2025Article
- Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury.Diagnostics (Basel, Switzerland) · 2025Article
- Effect of continuous hypertonic saline infusion on clinical outcomes in patients with traumatic brain injury.Neurosurgical review · 2024Article
- Identification of Demographic and Clinical Prognostic Factors in Traumatic Intraventricular Hemorrhage.Neurocritical care · 2023Review
- Inpatient Metabolic Panel Trajectories Improve 6-Month Mortality Prognostication after Severe Traumatic Brain Injury.Neurotrauma reportsArticle
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveDysnatremia is common in severe traumatic brain injury (TBI) patients and may contribute to mortality. However, serum sodium variability has not been studied in TBI patients. We hypothesized that such variability would be independently associated with mortality.
methodsWe collected 6-hourly serum sodium levels for the first 7 days of ICU admission from 240 severe TBI patients in 14 neurotrauma ICUs in Europe and Australia. We evaluated the association between daily serum sodium standard deviation (dNa
resultsPatients were 46 ± 19 years of age with a median initial GCS of 6 [4-8]. Overall hospital mortality was 28%. Hypernatremia and hyponatremia occurred in 64% and 24% of patients, respectively. Over the first 7 days in ICU, serum sodium standard deviation was 2.8 [2.0-3.9] mmol/L. Maximum daily serum sodium standard deviation (dNa
conclusionsOur study demonstrates that daily serum sodium variability is an independent predictor of 28-day mortality in severe TBI patients. Further prospective investigations are necessary to confirm the significance of sodium variability in larger cohorts of TBI patients and test whether attenuating such variability confers outcome benefits to such patients.
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