ReviewBiology of reproduction2021
In vitro models of the human endometrium: evolution and application for women's health.
Review in Biology of reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Bovine endometrial organoids: a new tool to study conceptus-maternal interactions in mammals†.Biology of reproduction · 2026Article
- ReducedInternational journal of molecular sciences · 2026Article
- UDEDB: A Comprehensive Database for Dynamic Molecular Expression Changes in Uterine Endometrium.Interdisciplinary sciences, computational life sciences · 2026Article
- Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol-Driven WNT7B Suppression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Endometrial Collagen in Woolly Monkey (Lagothrix l. poeppiggi) and the Uakari (Cacajao calvus).Journal of medical primatology · 2026Article
- Engineering human endometrial model systems in reproductive health and disease.npj biomedical innovations · 2025Review
- Embryo-maternal cross-talk: key players in successful implantation and live birth rates.Reproductive biology and endocrinology : RB&E · 2025Review
- Unlocking the Secrets of the Endometrium: Stem Cells, Niches and Modern Methodologies.Biomedicines · 2025Review
- Plasma Rich in Growth Factor (PRGF) Therapy for Endometrial Receptivity: A Promising Approach inJournal of pharmacy & bioallied sciences · 2025Article
- Mitochondrial dysfunction in pregnancy loss: a review.Molecular and cellular biochemistry · 2025Review
- The Comparative Study of Platelet Rich Plasma (PRP) and Plasma Rich in Growth factor (PRGF) in Endometrial Thickness, Implantation Rate and Pregnancy Outcomes in IVF Patients.Journal of pharmacy & bioallied sciences · 2025Article
- Enhancing Endometrial Receptivity Assessment Outcomes in Recurrent Implantation Failure: Intralipid Infusion and Acupuncture as Complementary Therapies.Journal of pharmacy & bioallied sciences · 2025Article
- Infertility treatment using polysaccharides-based hydrogels: new strategies in tissue engineering and regenerative medicine.Journal of nanobiotechnology · 2025Review
- The modeling of human implantation and early placentation: achievements and perspectives.Human reproduction update · 2025Review
- Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model.Scientific reports · 2025Article
- Establishment of an In Vitro Embryo-Endometrium Model Using Alginate-Embedded Mouse Embryos and Human Embryoid Body.Tissue engineering and regenerative medicine · 2025Article
- Obesity induced by a high-fat diet changes p62 protein levels in mouse reproductive organs.Journal of molecular histology · 2024Article
- Proteomics of Ishikawa endometrial cancer cells: impact of liposomal backbone.BMC research notes · 2024Article
- Article
- Current strategies using 3D organoids to establishJournal of veterinary science · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The endometrium is the inner lining of the uterus that undergoes complex regeneration and differentiation during the human menstrual cycle. The process of endometrial shedding, regeneration, and differentiation is driven by ovarian steroid hormones and prepares the endometrium and intrauterine environment for embryo implantation and pregnancy establishment. Endometrial glands and their secretions are essential for pregnancy establishment, and cross talk between the glandular epithelium and stromal cells appears vital for decidualization and placental development. Despite being crucial, the biology of the human endometrium during pregnancy establishment and most of pregnancy is incomplete, given the ethical and practical limitations of obtaining and studying endometrium from pregnant women. As such, in vitro models of the human endometrium are required to fill significant gaps in understanding endometrial biology. This review is focused on the evolution and development of in vitro three-dimensional models of the human endometrium and provides insight into the challenges and promises of those models to improve women's reproductive health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.