ArticleCommunications biology2020
High pressures increase α-chymotrypsin enzyme activity under perchlorate stress.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Study on Rapeseed Albumin Hydrolysis by PrtS Protease fromFoods (Basel, Switzerland) · 2025Article
- Article
- Preservation of Bacillus subtilis' cellular liquid state at deep sub-zero temperatures in perchlorate brines.Communications biology · 2024Article
- Structural Responses of Nucleic Acids to Mars-Relevant Salts at Deep Subsurface Conditions.Life (Basel, Switzerland) · 2022Article
- Perchlorate salts confer psychrophilic characteristics in α-chymotrypsin.Scientific reports · 2021Article
- General Counteraction Exerted by Sugars against Denaturants.Life (Basel, Switzerland) · 2021Article
- New thermodynamic activity-based approach allows predicting the feasibility of glycolysis.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep subsurface environments can harbour high concentrations of dissolved ions, yet we know little about how this shapes the conditions for life. We know even less about how the combined effects of high pressure influence the way in which ions constrain the possibilities for life. One such ion is perchlorate, which is found in extreme environments on Earth and pervasively on Mars. We investigated the interactions of high pressure and high perchlorate concentrations on enzymatic activity. We demonstrate that high pressures increase α-chymotrypsin enzyme activity even in the presence of high perchlorate concentrations. Perchlorate salts were shown to shift the folded α-chymotrypsin phase space to lower temperatures and pressures. The results presented here may suggest that high pressures increase the habitability of environments under perchlorate stress. Therefore, deep subsurface environments that combine these stressors, potentially including the subsurface of Mars, may be more habitable than previously thought.
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Registered trials
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