ArticleScientific reports2020
Pupil size changes signal hippocampus-related memory functions.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Beyond the locus coeruleus: pupil dynamics as a systems-level marker of neuromodulatory influences on hippocampal memory.Frontiers in molecular neuroscience · 2026Article
- Predicting long-term memory via pupillometry.Scientific reports · 2025Article
- Saccades track visual associative memory processes with precision and sensitivity.Brain communications · 2025Article
- Identifying the bioimaging features of Alzheimer's disease based on pupillary light response-driven brain-wide fMRI in awake mice.Nature communications · 2024Article
- A Pilot Study to Improve Cognitive Performance and Pupil Responses in Mild Cognitive Impaired Patients Using Gaze-Controlled Gaming.Vision (Basel, Switzerland) · 2024Article
- Effect of Cognitive Reserve on Physiological Measures of Cognitive Workload in Older Adults with Cognitive Impairments.Journal of Alzheimer's disease : JAD · 2023Article
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Authors and funding
3 authors.
Funding
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Abstract
A major task of episodic memory is to create unique, distinguishable representations of highly overlapping perceptual inputs. Several studies on this basic function have shown that it is based on the intact functioning of certain subregions of the hippocampus and is among the most sensitive behavioral indicators of mild cognitive impairment (MCI) and dementia. Here we assessed pupil dilation associated with performance in a widely used recognition paradigm that aims to uncover the intactness of fine-graded mnemonic discrimination. A sample of healthy undergraduate students was used. First, we showed that the correct discrimination between highly similar lure items and target items elicit larger pupil response than correct target identification. Second, we found that mnemonic discrimination is associated with larger pupil response in general as compared to target identification, regardless of whether the response was correct or not. These results suggest the pupil changes differentiate mnemonic discrimination and memory identification processes in recognition performance.
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Registered trials
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