Evidence map›Paper›PMID 33009451›Full record

ArticleScientific reports2020

Co-detection of Bordetella pertussis and other respiratory organisms in children hospitalised with lower respiratory tract infection.

Rudzani Muloiwa, Felix S Dube, Mark P Nicol, Gregory D Hussey, Heather J Zar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Rudzani MuloiwaDepartment of Paediatrics and Child Health, Groote Schuur Hospital, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa. Rudzani.Muloiwa@uct.ac.za.
Felix S DubeDepartment of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Cape Town, South Africa.
Mark P NicolDivision of Infection and Immunity, School of Biomedical Sciences, University of Western Australia, Crawley, Australia.
Gregory D HusseyInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Heather J ZarSA-MRC Unit On Child and Adolescent Lung Health, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAGroote Schuur Hospital · ZA

Funding

The nasopharyngeal microbiota of African children and lower respiratory tract infectionU54HG009824 · NHGRI · UNIVERSITY OF CAPE TOWN · PI NICOL, MARK PATRICK · 2017 to 2021
$2.9M
NHGRI NIH HHS U54 HG009824
6 · The paper itself

Abstract

Multiple potential pathogens are frequently co-detected among children with lower respiratory tract infection (LRTI). Evidence indicates that Bordetella pertussis has an important role in the aetiology of LRTI. We aimed to study the association between B. pertussis and other respiratory pathogens in children hospitalised with severe LRTI, and to assess clinical relevance of co-detection. Nasopharyngeal (NP) swabs and induced sputa (IS) were tested with a B. pertussis specific PCR; additionally, IS was tested for other pathogens using a multiplex PCR. We included 454 children, median age 8 months (IQR 4-18), 31 (7%) of whom tested positive for B. pertussis. Children with B. pertussis had more bacterial pathogens detected (3 versus 2; P < 0.001). While B. pertussis showed no association with most pathogens, it was independently associated with Chlamydia pneumoniae, Mycoplasma pneumoniae and parainfluenza viruses with adjusted risk ratios of 4.01 (1.03-15.64), 4.17 (1.42-12.27) and 2.13 (1.03-4.55), respectively. There was a consistent increased risk of severe disease with B. pertussis. Patterns indicated even higher risks when B. pertussis was co-detected with any of the three organisms although not statistically significant. Improving vaccine coverage against B. pertussis would impact not only the incidence of pertussis but also that of severe LRTI generally.

Indexed as

Bordetella pertussisChlamydophila pneumoniaeFemaleHospitalizationHumansIncidenceInfantMaleMultiplex Polymerase Chain ReactionMycoplasma pneumoniaeRespiratory Tract InfectionsRespirovirusSputumWhooping Cough

Identifiers

PMID33009451
PMCPMC7532201
OpenAlexW3091416075

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.