Evidence map›Paper›PMID 33009445›Full record

ArticleScientific reports2020

Conventional pulse transit times as markers of blood pressure changes in humans.

Robert C Block, Mohammad Yavarimanesh, Keerthana Natarajan, Andrew Carek, Azin Mousavi, Anand Chandrasekhar, Chang-Sei Kim, Junxi Zhu, Giovanni Schifitto, Lalit K Mestha and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05393401 (Photoplethysmographic Measurements of Pulse Wave Velocity), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05393401 narecruitingnot on this mapstarted 2022, after this paper: background citation

Photoplethysmographic Measurements of Pulse Wave Velocity (PWV) and Blood Pressure (BP) MEPPAVOP

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2022 to 2026Enrolled27ConditionsHealthy VolunteersArmsVOP1k
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 91 citations in OpenAlex.

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  11. Another example of Aslanger' s sign.Journal of geriatric cardiology : JGC · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Robert C Block *Department of Public Health Sciences, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Mohammad Yavarimanesh *Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA.
Keerthana NatarajanDepartment of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA.
Andrew CarekSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Azin MousaviDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Anand ChandrasekharDepartment of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA.
Chang-Sei KimSchool of Mechanical Engineering, Chonnam National University, Gwangju, Korea.
Junxi ZhuDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Giovanni SchifittoDepartments of Neurology and Imaging, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Lalit K MesthaDepartment of Electrical Engineering, University of Texas, Arlington, TX, USA.
Omer T InanSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Jin-Oh HahnDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Ramakrishna MukkamalaDepartment of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA. rmukkamala@pitt.edu.
Michigan State University · USUniversity of Maryland, College Park · USGeorgia Institute of Technology · USUniversity of Rochester · USChonnam National University · KRThe University of Texas at Arlington · USUniversity of Pittsburgh · US

Funding

Unobtrusive and Affordable Blood Pressure Monitoring Via Pulse Transit TimeU01EB018818 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MUKKAMALA, RAMAKRISHNA · 2014 to 2018
$3.4M
NIBIB NIH HHS U01 EB018818NIH HHS EB018818
6 · The paper itself

Abstract

Pulse transit time (PTT) represents a potential approach for cuff-less blood pressure (BP) monitoring. Conventionally, PTT is determined by (1) measuring (a) ECG and ear, finger, or toe PPG waveforms or (b) two of these PPG waveforms and (2) detecting the time delay between the waveforms. The conventional PTTs (cPTTs) were compared in terms of correlation with BP in humans. Thirty-two volunteers [50% female; 52 (17) (mean (SD)) years; 25% hypertensive] were studied. The four waveforms and manual cuff BP were recorded before and after slow breathing, mental arithmetic, cold pressor, and sublingual nitroglycerin. Six cPTTs were detected as the time delays between the ECG R-wave and ear PPG foot, R-wave and finger PPG foot [finger pulse arrival time (PAT)], R-wave and toe PPG foot (toe PAT), ear and finger PPG feet, ear and toe PPG feet, and finger and toe PPG feet. These time delays were also detected via PPG peaks. The best correlation by a substantial extent was between toe PAT via the PPG foot and systolic BP [- 0.63 ± 0.05 (mean ± SE); p < 0.001 via one-way ANOVA]. Toe PAT is superior to other cPTTs including the popular finger PAT as a marker of changes in BP and systolic BP in particular.

Indexed as

BiomarkersBlood PressureBlood Pressure DeterminationElectrocardiographyFemaleFingersHeart RateHumansMaleMiddle AgedMonitoring, PhysiologicPhotoplethysmographyPulse Wave AnalysisRespiratory RateBiomarkers

Identifiers

PMID33009445
PMCPMC7532447
OpenAlexW3089500187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.