Evidence map›Paper›PMID 33009438›Full record

ArticleScientific reports2020

Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study.

Nicolai A Lund-Blix, German Tapia, Karl Mårild, Anne Lise Brantsæter, Merete Eggesbø, Siddhartha Mandal, Lars C Stene, Ketil Størdal

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Nicolai A Lund-BlixDepartment of Chronic Diseases and Ageing, Division for Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
German TapiaDepartment of Chronic Diseases and Ageing, Division for Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
Karl MårildDepartment of Chronic Diseases and Ageing, Division for Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
Anne Lise BrantsæterDepartment of Environmental Exposure and Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Merete EggesbøDepartment of Environmental Exposure and Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Siddhartha MandalCenter for Chronic Disease Control, New Delhi, India.
Lars C SteneDepartment of Chronic Diseases and Ageing, Division for Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
Ketil StørdalDepartment of Chronic Diseases and Ageing, Division for Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway. ketil.stordal@fhi.no.
Norwegian Institute of Public Health · NOCentre for Chronic Disease Control · INOslo University Hospital · NOØstfold Hospital Trust · NOUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal diet can influence the developing immune system of the offspring. We hypothesized that maternal fibre and gluten intake during pregnancy were associated with the risk of celiac disease in the child. In the Norwegian Mother, Father and Child Cohort Study (MoBa, n = 85,898) higher maternal fibre intake (median 29.5 g/day) was associated with a lower risk of celiac disease in the offspring (adjusted relative risk 0.90, 95% CI 0.83 to 0.98 per 10 g/d increase). Gluten intake during pregnancy (median 13.0 g/d) was associated with a higher risk of childhood CD (adjusted relative risk = 1.21, 95% CI 1.02 to 1.43 per 10 g/d increase). These results were largely unaffected by adjustment for the child's gluten intake at 18 months. In an independent study of 149 mother/child dyads, maternal fibre intake did not predict concentrations of total or sub-types of short-chain fatty acids in repeated infant stool samples, or fecal microbiome diversity in the mother or child. Our results suggest that high fibre and low gluten intake during pregnancy could be protective factors for celiac disease, although the mechanism is unknown.

Indexed as

AdultCeliac DiseaseDietDietary FiberFemaleGlutensHumansNorwayPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsDietary FiberGlutens

Identifiers

PMID33009438
PMCPMC7532434
OpenAlexW3089506355

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.