Evidence map›Paper›PMID 33009074›Full record

ArticleCritical pathways in cardiology2020

Unusual Fatigue and Failure to Utilize EMS Are Associated With Prolonged Prehospital Delay for Suspected Acute Coronary Syndrome.

Holli A DeVon, Mohamud R Daya, Elizabeth Knight, Mary-Lynn Brecht, Erica Su, Jessica Zègre-Hemsey, Sahereh Mirzaei, Stephanie Frisch, Anne G Rosenfeld

Abstract read
In one paragraph

Article in Critical pathways in cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Holli A DeVonFrom the University of California Los Angeles, School of Nursing, Los Angeles, CA.
Mohamud R DayaOregon Health and Science University, School of Medicine, Portland, OR.
Elizabeth KnightOregon Health and Science University, School of Medicine, Portland, OR.
Mary-Lynn BrechtFrom the University of California Los Angeles, School of Nursing, Los Angeles, CA.
Erica SuDepartment of Biostatistics, University of California Los Angeles, Los Angeles, CA.
Jessica Zègre-HemseyUniversity of North Carolina, School of Nursing, Chapel Hill, NC.
Sahereh MirzaeiFrom the University of California Los Angeles, School of Nursing, Los Angeles, CA.
Stephanie FrischUniversity of Pittsburgh, School of Nursing, Pittsburgh, PA.
Anne G RosenfeldUniversity of Arizona, College of Nursing, Tucson, AZ.

Funding

Characterizing Prehospital Delay and Outcomes in Patients Treated for Potential Acute Coronary Syndrome in the Emergency DepartmentR21HL140277 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DEVON, HOLLI A · 2018 to 2019
$278k
Modernizing Emergency Department Nurse Triage via Big Data AnalyticsF31NR018589 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRISCH, STEPHANIE O. · 2019 to 2020
$59k
NHLBI NIH HHS R21 HL140277NINR NIH HHS F31 NR018589
6 · The paper itself

Abstract

backgroundRapid reperfusion reduces infarct size and mortality for acute coronary syndrome (ACS), but efficacy is time dependent. The aim of this study was to determine if transportation factors and clinical presentation predicted prehospital delay for suspected ACS, stratified by final diagnosis (ACS vs. no ACS).

methodsA heterogeneous sample of emergency department (ED) patients with symptoms suggestive of ACS was enrolled at 5 US sites. Accelerated failure time models were used to specify a direct relationship between delay time and variables to predict prehospital delay by final diagnosis.

resultsEnrolled were 609 (62.5%) men and 366 (37.5%) women, predominantly white (69.1%), with a mean age of 60.32 (±14.07) years. Median delay time was 6.68 (confidence interval 1.91, 24.94) hours; only 26.2% had a prehospital delay of 2 hours or less. Patients presenting with unusual fatigue [time ratio (TR) = 1.71, P = 0.002; TR = 1.54, P = 0.003, respectively) or self-transporting to the ED experienced significantly longer prehospital delay (TR = 1.93, P < 0.001; TR = 1.71, P < 0.001, respectively). Predictors of shorter delay in patients with ACS were shoulder pain and lightheadedness (TR = 0.65, P = 0.013 and TR = 0.67, P = 0.022, respectively). Predictors of shorter delay for patients ruled out for ACS were chest pain and sweating (TR = 0.071, P = 0.025 and TR = 0.073, P = 0.032, respectively).

conclusionPatients self-transporting to the ED had prolonged prehospital delays. Encouraging the use of EMS is important for patients with possible ACS symptoms. Calling 911 can be positively framed to at-risk patients and the community as having advanced care come to them because EMS capabilities include 12-lead ECG acquisition and possibly high-sensitivity troponin assays.

Indexed as

Acute Coronary SyndromeAgedChest PainElectrocardiographyEmergency Service, HospitalFatigueFemaleHumansMaleMiddle Aged

Identifiers

PMID33009074
PMCPMC7669539

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.