ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Analysis of Parvocellular and Magnocellular Visual Pathways in Human Retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Diagnostic accuracy of isolated-check visual evoked potentials for glaucoma: a systematic review and meta-analysis.BMC ophthalmology · 2025Pooled it
- Trial
- Approaching a connectome of the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dissociable effects of element-lifetime and stimulus-duration on local and global motion processing: An equivalent noise study.Journal of vision · 2026Article
- Physiological basis of resolution acuity in vision.Nature communications · 2026Article
- Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026Article
- Article
- Amacrine cell inputs to OFF midget ganglion cells in macaque retina.The Journal of physiology · 2025Article
- The spatial and temporal properties of the contour erasure effect and perceptual filling-in.Journal of vision · 2025Article
- Visual Neuroplasticity: Modulating Cortical Excitability with Flickering Light Stimulation.Journal of imaging · 2025Article
- Spatial Distribution and Morphology of CaMKII-Expressing Amacrine Cells in Marmoset, Macaque, and Human Retina.The Journal of comparative neurology · 2025Article
- Temporal acuity of vision decreases with eccentricity in virtual reality and is associated with schizotypy.Scientific reports · 2025Article
- Selective Effects of Ongoing Alpha-Band Activity on Magno- and Parvo-Mediated Detection.Psychophysiology · 2025Article
- The Predictive and Explanatory Power of the Contrast Theory of Myopia.Translational vision science & technology · 2025Article
- Immunohistochemistry and Spatial Density of Müller Cells in the Human Fovea.Investigative ophthalmology & visual science · 2025Article
- Clinical anatomy of the macula.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Review
- The role of RGC degeneration in the pathogenesis of glaucoma.International journal of biological sciences · 2025Review
- Impact of Deprivation and Preferential Usage on Functional Connectivity Between Early Visual Cortex and Category-Selective Visual Regions.Human brain mapping · 2024Article
- Diffusion Optics Technology (DOT): A Myopia Control Spectacle Lens Based on Contrast Theory.Translational vision science & technology · 2024Review
- Environmental Lighting Conditions, Phenomenal Contrast, and the Conscious Perception of Near and Far.Brain sciences · 2024Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two main subcortical pathways serving conscious visual perception are the midget-parvocellular (P), and the parasol-magnocellular (M) pathways. It is generally accepted that the P pathway serves red-green color vision, but the relative contribution of P and M pathways to spatial vision is a long-standing and unresolved issue. Here, we mapped the spatial sampling properties of P and M pathways across the human retina. Data were obtained from immunolabeled vertical sections of six postmortem male and female human donor retinas and imaged using high-resolution microscopy. Cone photoreceptors, OFF-midget bipolar cells (P pathway), OFF-diffuse bipolar (DB) types DB3a and DB3b (M pathway), and ganglion cells were counted along the temporal horizontal meridian, taking foveal spatial distortions (postreceptoral displacements) into account. We found that the density of OFF-midget bipolar and OFF-midget ganglion cells can support one-to-one connections to 1.05-mm (3.6°) eccentricity. One-to-one connections of cones to OFF-midget bipolar cells are present to at least 10-mm (35°) eccentricity. The OFF-midget ganglion cell array acuity is well-matched to photopic spatial acuity measures throughout the central 35°, but the OFF-parasol array acuity is well below photopic spatial acuity, supporting the view that the P pathway underlies high-acuity spatial vision. Outside the fovea, array acuity of both OFF-midget and OFF-DB cells exceeds psychophysical measures of photopic spatial acuity. We conclude that parasol and midget pathway bipolar cells deliver high-acuity spatial signals to the inner plexiform layer, but outside the fovea, this spatial resolution is lost at the level of ganglion cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.