ArticleThe European respiratory journal2021
Temporal airway microbiome changes related to ventilator-associated pneumonia in children.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Endotracheal Tube-Associated Complications in Paediatric Critical Care: A Systematic Review and Meta-Analysis.Nursing in critical care · 2025Pooled it
- Short-term exposure to ambient fine particulate pollution aggravates ventilator-associated pneumonia in pediatric intensive care patients undergoing cardiovascular surgeries.Environmental health : a global access science source · 2023Trial
- The Role of the Respiratory Microbiome in Pneumonia.Clinics in chest medicine · 2026Review
- Host-microbiome archetypes differentiate infection from pathogen carriage in the human lower airway.Nature communications · 2026Article
- Microbial signatures and host immune responses associated with the development of ventilator-associated pneumonia among patients with neurological injuries.Microbiology spectrum · 2026Article
- Longitudinal analysis of lung microbiome, immune response, and metabolism in ventilator-associated pneumonia: a cohort study.Critical care (London, England) · 2025Article
- Multiplex Polymerase Chain Reaction Versus Standard Bacterial Culture in Critically Ill Children With Suspected Pneumonia.The Pediatric infectious disease journal · 2025Article
- Airway Colonization in Children with Medical Complexity: Challenges and Management Strategies.Journal of clinical medicine · 2025Review
- Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections.mSystems · 2025Article
- Integrative study of pulmonary microbiome, transcriptome and clinical outcomes in Mycoplasma pneumoniae pneumonia.Respiratory research · 2024Article
- The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients.Nature communications · 2024Observational
- Limited effects of azithromycin on the oropharyngeal microbiome in children with CF and early pseudomonas infection.BMC microbiology · 2023Article
- Integrated host/microbe metagenomics enables accurate lower respiratory tract infection diagnosis in critically ill children.The Journal of clinical investigation · 2023Article
- Utilizing metagenomic next-generation sequencing for diagnosis and lung microbiome probing of pediatric pneumonia through bronchoalveolar lavage fluid in pediatric intensive care unit: results from a large real-world cohort.Frontiers in cellular and infection microbiology · 2023Article
- Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study.Scientific reports · 2022Article
- Lower respiratory tract infections in children requiring mechanical ventilation: a multicentre prospective surveillance study incorporating airway metagenomics.The Lancet. Microbe · 2022Article
- Airway microbiome dynamics and relationship to ventilator-associated infection in intubated pediatric patients.Pediatric pulmonology · 2022Article
Corrections and comments
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Authors and funding
29 authors at 12 institutions in 1 country.
Peter M MouraniPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Marci K SontagEpidemiology, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.
Kayla M WilliamsonBiostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.
J Kirk HarrisPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Ron ReederPediatrics, University of Utah, Salt Lake City, UT, USA.
Chris LocandroPediatrics, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0003-0472-8237
Todd C CarpenterPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Aline B MadduxPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Katherine ZieglerEpidemiology, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.
Eric A F SimõesPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Christina M OsbornePediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.ORCID https://orcid.org/0000-0001-5319-7343
Lilliam AmbroggioPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Matthew K LerouePediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Charles E RobertsonMedicine, Division of Infectious Diseases, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.ORCID https://orcid.org/0000-0002-4136-4121
Charles LangelierMedicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, CA, USA.
Joseph L DeRisiChan Zuckerberg Biohub, San Francisco, CA, USA.
Jack KammChan Zuckerberg Biohub, San Francisco, CA, USA.ORCID https://orcid.org/0000-0003-2412-756X
Mark W HallDept of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.
Athena F ZuppaAnesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Joseph CarcilloPediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Kathleen MeertPediatrics, Children's Hospital of Michigan, Detroit, MI, USA.
Anil SapruPediatrics, University of California Los Angeles, Los Angeles, CA, USA.
Murray M PollackPediatrics, Children's National Medical Center and George Washington School of Medicine and Health Sciences, Washington, DC, USA.
Patrick McQuillenPediatrics, University of California San Francisco, San Francisco, CA, USA.
Daniel A NottermanMolecular Biology, Princeton University, Princeton, NJ, USA.
J Michael DeanPediatrics, University of Utah, Salt Lake City, UT, USA.
Brandie D WagnerBiostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.ORCID https://orcid.org/0000-0002-2745-0103
Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)
Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) members are as follows:
Children's Hospital Colorado · USColorado School of Public Health · USUniversity of California, San Francisco · USUniversity of Utah · USChan Zuckerberg Initiative (United States) · USChildren's Hospital of Michigan · USChildren's Hospital of Philadelphia · USChildren's National · USNationwide Children's Hospital · USPrinceton University · USUniversity of California, Los Angeles · USUniversity of Pittsburgh · US
Funding
Data Coordinating Center for the Collaborative Pediatric Critical Care Research NetworkU01HD049934 · NICHD · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2005 to 2020
$35.2MMetoclopramide prevents PICU nosocomial infectionU10HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2005 to 2014
$3.1MThe Microbiome, Virome and Host Responses Preceding Ventilator-Associated PneumonR01HL124103 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOURANI, PETER M, SONTAG, MARCI K · 2014 to 2017
$2.7MCollaborative Pediatric Critical Care Research Network (CPCCRN) at Children's NationalUG1HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI POLLACK, MURRAY MICHAEL, WESSEL, DAVID LLOYD · 2015 to 2020
$1.8MPediatric Critical Care Research Network at Children's Hospital of PhiladelphiaUG1HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, ZUPPA, ATHENA F. · 2015 to 2020
$1.7MCollaborative Research to Validate Biomarkers of Pediatric ARDSUG1HD083166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN, SAPRU, ANIL · 2015 to 2020
$1.6MIntegrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill ChildrenR01HL155418 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGELIER, CHARLES · 2021 to 2024
$1.6MRenewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6MCollaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6MCollaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory FailureUG1HD083171 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARPENTER, TODD C · 2015 to 2020
$1.5MCollaborative Pediatric Critical Care Research Network (UG1)UG1HD083170 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HALL, MARK W · 2015 to 2020
$1.5MCollaborative Pediatric Critical Care Research Network - Clinical SiteRL1HD107773 · NICHD · CENTRAL MICHIGAN UNIVERSITY · PI KATHLEEN L. MEERT · 2021 to 2026
$862kNHLBI NIH HHS K23 HL138461NHLBI NIH HHS R01 HL124103NHLBI NIH HHS R01 HL155418NICHD NIH HHS K23 HD096018NICHD NIH HHS RL1 HD107773NICHD NIH HHS U01 HD049934NICHD NIH HHS U10 HD049983NICHD NIH HHS UG1 HD049981NICHD NIH HHS UG1 HD049983NICHD NIH HHS UG1 HD050096NICHD NIH HHS UG1 HD063108NICHD NIH HHS UG1 HD083166NICHD NIH HHS UG1 HD083170NICHD NIH HHS UG1 HD083171
Abstract
We sought to determine whether temporal changes in the lower airway microbiome are associated with ventilator-associated pneumonia (VAP) in children.Using a multicentre prospective study of children aged 31 days to 18 years requiring mechanical ventilation support for >72 h, daily tracheal aspirates were collected and analysed by sequencing of the 16S rRNA gene. VAP was assessed using 2008 Centers for Disease Control and Prevention paediatric criteria. The association between microbial factors and VAP was evaluated using joint longitudinal time-to-event modelling, matched case-control comparisons and unsupervised clustering.Out of 366 eligible subjects, 66 (15%) developed VAP at a median of 5 (interquartile range 3-5) days post intubation. At intubation, there was no difference in total bacterial load (TBL), but Shannon diversity and the relative abundance of
Indexed as
MicrobiotaPneumonia, Ventilator-AssociatedChildHumansIntensive Care UnitsProspective StudiesRNA, Ribosomal, 16SRNA, Ribosomal, 16S
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