Evidence map›Paper›PMID 33008927›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Photoacoustic Molecular Imaging for the Identification of Lymph Node Metastasis in Head and Neck Cancer Using an Anti-EGFR Antibody-Dye Conjugate.

Naoki Nishio, Nynke S van den Berg, Brock A Martin, Stan van Keulen, Shayan Fakurnejad, Eben L Rosenthal, Katheryne E Wilson

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Translation of Intraoperative Molecular Imaging for Clinical Use.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Recent advances in head and neck surgical oncology.Journal of surgical oncology · 2024
    Review
  11. Photoacoustics · 2023
    Article
  12. Evaluation of cervical lymph nodes using multispectral optoacoustic tomography: a proof-of-concept study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  13. Article
  14. Photoacoustics · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Precision Surgery Guided by Intraoperative Molecular Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Naoki NishioDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
Nynke S van den BergDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
Brock A MartinDepartment of Pathology, Stanford University School of Medicine, Stanford, California; and.
Stan van KeulenDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
Shayan FakurnejadDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
Eben L RosenthalDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
Katheryne E WilsonDepartment of Radiology, Stanford University School of Medicine, Stanford, California wilsonk2@stanford.edu.
Stanford University · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Prototype optical device for image guided surgery with panitumumab-IRDye800R01CA190306 · NCI · STANFORD UNIVERSITY · PI ROSENTHAL, EBEN L. · 2015 to 2019
$2.6M
Molecular Spectroscopic Photoacoustic Imaging for Breast Lesion CharacterizationR21EB022214 · NIBIB · STANFORD UNIVERSITY · PI WILSON, KATHERYNE E · 2016 to 2017
$439k
Spectroscopic Photoacoustic Molecular Imaging for Breast Lesion CharacterizationK99EB023279 · NIBIB · STANFORD UNIVERSITY · PI WILSON, KATHERYNE E · 2017 to 2018
$152k
NCI NIH HHS R01 CA190306NIBIB NIH HHS K99 EB023279NIBIB NIH HHS R21 EB022214
6 · The paper itself

Abstract

The presence of lymph node (LN) metastases is an essential prognostic indicator in patients with head and neck squamous cell carcinoma (HNSCC). This study assessed photoacoustic molecular imaging (PAMI) of the antiepidermal growth factor receptor antibody (panitumumab) conjugated to a near-infrared fluorescent dye, IRDye800CW (panitumumab-IRDye800CW; pan800), for the identification of occult metastatic LNs in patients with HNSCC (

Indexed as

Molecular ImagingPhotoacoustic TechniquesAdultColoring AgentsErbB ReceptorsFemaleHead and Neck NeoplasmsHumansImmunoconjugatesLymphatic MetastasisMaleMiddle AgedColoring AgentsErbB ReceptorsImmunoconjugatesantibody–dyehead and neck cancerlymph nodenear-infraredphotoacoustic imaging

Identifiers

PMID33008927
PMCPMC8844260
OpenAlexW3089465630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.