Evidence map›Paper›PMID 33008918›Full record

ArticleMolecular pharmacology2020

Domain-Swap Dimerization of

Vandna Sharma, Brian Shing, Lilian Hernandez-Alvarez, Anjan Debnath, Larissa M Podust

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Silver(I)-NHC Complexes as Dual-Action Agents Against PathogenicInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Vandna SharmaSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California (V.S., B.S., L.H.-A., A.D., L.M.P.) and Departamento de Física, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista Julio de Mesquita Filho, São José do Rio Preto, São Paulo, Brazil (L.H.-A.).ORCID 0000-0002-3054-2658
Brian ShingSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California (V.S., B.S., L.H.-A., A.D., L.M.P.) and Departamento de Física, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista Julio de Mesquita Filho, São José do Rio Preto, São Paulo, Brazil (L.H.-A.).ORCID 0000-0002-5579-8940
Lilian Hernandez-AlvarezSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California (V.S., B.S., L.H.-A., A.D., L.M.P.) and Departamento de Física, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista Julio de Mesquita Filho, São José do Rio Preto, São Paulo, Brazil (L.H.-A.).ORCID 0000-0001-5681-6293
Anjan DebnathSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California (V.S., B.S., L.H.-A., A.D., L.M.P.) and Departamento de Física, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista Julio de Mesquita Filho, São José do Rio Preto, São Paulo, Brazil (L.H.-A.).ORCID 0000-0001-9294-3927
Larissa M PodustSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California (V.S., B.S., L.H.-A., A.D., L.M.P.) and Departamento de Física, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista Julio de Mesquita Filho, São José do Rio Preto, São Paulo, Brazil (L.H.-A.) lpodust@health.ucsd.edu.ORCID 0000-0002-8537-8760
Center for Discovery · US

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Brain Penetrant Microtubule-Stabilizers to Treat CNS-invasive Parasitic DiseasesR21AI141210 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BALLATORE, CARLO, CAFFREY, CONOR · 2019 to 2020
$441k
HMG-CoA Reductase Inhibitors as New Drug Leads for Naegleria InfectionR21AI146460 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEBNATH, ANJAN · 2020 to 2021
$433k
Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseasesR21AI133394 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BALLATORE, CARLO, CAFFREY, CONOR · 2018 to 2019
$426k
NCATS NIH HHS KL2 TR001444NIAID NIH HHS R21 AI133394NIAID NIH HHS R21 AI141210NIAID NIH HHS R21 AI146460
6 · The paper itself

Abstract

Cytochromes P450 (P450, CYP) metabolize a wide variety of endogenous and exogenous lipophilic molecules, including most drugs. Sterol 14

Indexed as

14-alpha Demethylase InhibitorsAcanthamoeba castellaniiAmebiasisCrystallography, X-RayHumansMolecular Dynamics SimulationNitrilesProtein BindingProtein DomainsProtein MultimerizationProteolysisProtozoan ProteinsPyridinesRecombinant ProteinsSterol 14-DemethylaseTriazoles14-alpha Demethylase InhibitorsisavuconazoleNitrilesProtozoan ProteinsPyridinesRecombinant ProteinsSterol 14-DemethylaseTriazoles

Identifiers

PMID33008918
PMCPMC7674934
OpenAlexW3091300144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.