ArticleProceedings of the National Academy of Sciences of the United States of America2020
Dynamic and reversible shape response of red blood cells in synthetic liquid crystals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Influence of the glycocalyx on the size and mechanical properties of plasma membrane-derived vesicles.Soft matter · 2025Article
- Shaping Liquid Droplets on an Active Air-Ferrofluid Interface.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Competition between deformation and free volume quantified by 3D image analysis of red blood cell.Biophysical journal · 2023Article
- Programmable self-propelling actuators enabled by a dynamic helical medium.Science advances · 2021Article
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4 authors.
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Abstract
Mammalian cells are soft, and correct functioning requires that cells undergo dynamic shape changes in vivo. Although a range of diseases are associated with stiffening of red blood cells (RBCs; e.g., sickle cell anemia or malaria), the mechanical properties and thus shape responses of cells to complex viscoelastic environments are poorly understood. We use vapor pressure measurements to identify aqueous liquid crystals (LCs) that are in osmotic equilibrium with RBCs and explore mechanical coupling between RBCs and LCs. When transferred from an isotropic aqueous phase into a LC, RBCs exhibit complex yet reversible shape transformations, from initially biconcave disks to elongated and folded geometries with noncircular cross-sections. Importantly, whereas the shapes of RBCs are similar in isotropic fluids, when strained by LC, a large variance in shape response is measured, thus unmasking cell-to-cell variation in mechanical properties. Numerical modeling of LC and cell mechanics reveals that RBC shape responses occur at constant cell membrane area but with membrane shear moduli that vary between cells from 2 to 16 × 10
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