ArticleeNeuro
The Home-Cage Automated Skilled Reaching Apparatus (HASRA): Individualized Training of Group-Housed Mice in a Single Pellet Reaching Task.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Toward video-LLM driven workflow for behavioral segmentation and scoring in mice performing a skilled water-reaching task: an evaluation of recent LLM models.Neurophotonics · 2026Article
- Protocol to design and implement scalable wireless network system for high-throughput, automated behavioral and circuit neuroscience in mice.STAR protocols · 2026Article
- A paradigm for skilled forelimb reaching by head-restrained mice.bioRxiv : the preprint server for biology · 2026Article
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- Repeated tDCS at Clinically Relevant Field Intensity Can Boost Concurrent Motor Learning in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Home cage-based insights into motor learning and strategy adaptation in a Huntington disease mouse model.PloS one · 2025Article
- AutoRG: An automatized reach-to-grasp platform technology for assessing forelimb motor function, neural circuit activation, and cognition in rodents.Journal of neuroscience methods · 2023Article
- The Emergence of Stereotyped Kinematic Synergies when Mice Reach to Grasp Following Stroke.Neurorehabilitation and neural repair · 2022Article
- Impaired Refinement of Kinematic Variability in Huntington Disease Mice on an Automated Home Cage Forelimb Motor Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Closed-loop automated reaching apparatus (CLARA) for interrogating complex motor behaviors.Journal of neural engineering · 2021Article
- Automation of training and testing motor and related tasks in pre-clinical behavioural and rehabilitative neuroscience.Experimental neurology · 2021Review
- When Spinal Neuromodulation Meets Sensorimotor Rehabilitation: Lessons Learned From Animal Models to Regain Manual Dexterity After a Spinal Cord Injury.Frontiers in rehabilitation sciences · 2021Review
- Localizing Microemboli within the Rodent Brain through Block-Face Imaging and Atlas Registration.eNeuroArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The single pellet reaching task is commonly used in rodents to assess the acquisition of fine motor skill and recovery of function following nervous system injury. Although this task is useful for gauging skilled forelimb use in rodents, the process of training animals is labor intensive and variable across studies and labs. To address these limitations, we developed a single pellet reaching paradigm for training and testing group housed mice within their home cage. Mice enter a training compartment attached to the outside of the cage and retrieve millet seeds presented on a motorized pedestal that can be individually positioned to present seeds to either forelimb. To identify optimal training parameters, we compared task participation and success rates between groups of animals that were presented seeds at two different heights (floor vs mouth height) and at different intervals (fixed-time vs trial-based). The mouth height/fixed interval presentation style was most effective at promoting reaching behavior as all mice reached for seeds within 5 d. Using this paradigm, we assessed stroke-induced deficits in home-cage reaching. Following three weeks of baseline training, reaching success rate was ∼40%, with most trials performed during the dark cycle. A forelimb motor cortex stroke significantly decreased interaction with presented seeds within the first 2 d and impaired reaching success rates for the first 7 d. Our data demonstrate that group-housed mice can be efficiently trained on a single pellet reaching task in the home cage and that this assay is sensitive to stroke induced motor impairments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.