Evidence map›Paper›PMID 33008575›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2022

Influence of broader geographic allograft sharing on outcomes and cost in smaller lung transplant centers.

Nathan Haywood, J Hunter Mehaffey, Sarah Kilbourne, Hannah Mannem, Max Weder, Christine Lau, Alexander S Krupnick, Avinash Agarwal

Abstract read
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Activation of donor-derived eosinophils during static storage contributes to primary graft dysfunction after lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Same-teams versus different-teams for long distance lung procurement: A cost analysis.The Journal of thoracic and cardiovascular surgery · 2023
    Article
  6. Commentary: From Locke to Merton to lung allocation: Unintended consequences.The Journal of thoracic and cardiovascular surgery · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Commentary: Malpractice in heart transplantation.Journal of cardiac surgery · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nathan HaywoodDivision of Thoracic & Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Va.
J Hunter MehaffeyDivision of Thoracic & Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Va.
Sarah KilbourneDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia Health System, Charlottesville, Va.
Hannah MannemDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia Health System, Charlottesville, Va.
Max WederDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia Health System, Charlottesville, Va.
Christine LauDivision of Thoracic Surgery, Department of Surgery, University of Maryland Medical Center, Baltimore, Md.
Alexander S KrupnickDivision of Thoracic Surgery, Department of Surgery, University of Maryland Medical Center, Baltimore, Md.
Avinash AgarwalDivision of Transplantation, Department of Surgery, University of Virginia Health System, Charlottesville, Va. Electronic address: AA4VB@virginia.edu.

Funding

The Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI Daniel Kreisel · 2015 to 2026
$19.4M
Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
The Role of Eosinophils in the Lung AllograftR01AI145108 · NIAID · UNIVERSITY OF VIRGINIA · PI Elizabeth A Jacobsen, ALEXANDER S. KRUPNICK · 2019 to 2026
$4.1M
NHLBI NIH HHS T32 HL007849NIAID NIH HHS P01 AI116501NIAID NIH HHS R01 AI145108
6 · The paper itself

Abstract

objectiveOn November 24, 2017, Organ Procurement and Transplantation Network implemented a change to lung allocation replacing donor service area with a 250 nautical mile radius around donor hospitals. We sought to evaluate the experience of a small to medium size center following implementation.

methodsPatients (47 pre and 54 post) undergoing lung transplantation were identified from institutional database from January 2016 to October 2019. Detailed chart review and analysis of institutional cost data was performed. Univariate analysis was performed to compare eras.

resultsSimilar short-term mortality and primary graft dysfunction were observed between groups. Decreased local donation (68% vs 6%; P < .001), increased travel distance (145 vs 235 miles; P = .004), travel cost ($8626 vs $14,482; P < .001), and total procurement cost ($60,852 vs $69,052; P = .001) were observed postimplementation. We also document an increase in waitlist mortality postimplementation (6.9 vs 31.6 per 100 patient-years; P < .001).

conclusionsFollowing implementation of the new allocation policy in a small to medium size center, several changes were in accordance with policy intention. However, concerning shifts emerged, including increased waitlist mortality and resource utilization. Continued close monitoring of transplant centers stratified by size and location are paramount to maintaining global availability of lung transplantation to all Americans regardless of geographic residence or socioeconomic status.

Indexed as

Lung DiseasesLung TransplantationResource AllocationTissue and Organ ProcurementDatabases, FactualFemaleGraft RejectionHealth Services AccessibilityHospitals, Low-VolumeHumansMaleMiddle AgedMortalityNeeds AssessmentOrganizational InnovationTissue Donorslung allocationlung donationlung transplantation

Identifiers

PMID33008575
PMCPMC7474916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.