Evidence map›Paper›PMID 33008522›Full record

ReviewHandbook of clinical neurology2020

Sex and the dopaminergic system: Insights from addiction studies.

Eric A Woodcock, Yasmin Zakiniaeiz, Evan D Morris, Kelly P Cosgrove

Open access · greenAbstract readReview
In one paragraph

Review in Handbook of clinical neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Review
  5. A sex-specific effect of MFrontiers in molecular neuroscience · 2024
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Eric A WoodcockDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States; Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States; Yale Positron Emission Tomography (PET) Center, Yale University, New Haven, CT, United States.
Yasmin ZakiniaeizDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States; Yale Positron Emission Tomography (PET) Center, Yale University, New Haven, CT, United States.
Evan D MorrisDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States; Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States; Department of Biomedical Engineering, Yale University, New Haven, CT, United States; Department of Biomedical Engineering, Yale University, New Haven, CT, United States; Invicro, LLC, New Haven, CT, United States.
Kelly P CosgroveDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States; Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States; Yale Positron Emission Tomography (PET) Center, Yale University, New Haven, CT, United States. Electronic address: kelly.cosgrove@yale.edu.
Yale University · USInvicro (United States) · US

Funding

Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Marina R Picciotto · 2020 to 2026
$13.0M
Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
Does Dopamine Mediate Effects of Stress on Inhibitory Control and Smoking Lapse?R01DA045465 · NIDA · YALE UNIVERSITY · PI MORRIS, EVAN D · 2018 to 2023
$5.3M
Imaging sex differences in smoking-induced dopamine release via novel PET methodsR01DA038709 · NIDA · YALE UNIVERSITY · PI MORRIS, EVAN D · 2015 to 2020
$3.7M
Imaging Molecular Mechanisms of Tobacco Smoking WithdrawalR01DA038832 · NIDA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2016 to 2021
$3.6M
Sex-Appropriate Treatment Development for Alcohol Use DisordersP01AA027473 · NIAAA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2018 to 2019
$1.0M
Multimodal Investigation of the Neuroimmune System in Opioid Use DisorderK99DA048125 · NIDA · YALE UNIVERSITY · PI WOODCOCK, ERIC ANDREW · 2019 to 2020
$334k
NIAAA NIH HHS P01 AA027473NIAAA NIH HHS U54 AA027989NIDA NIH HHS K99 DA048125NIDA NIH HHS R01 DA038709NIDA NIH HHS R01 DA038832NIDA NIH HHS R01 DA045465NIDA NIH HHS T32 DA022975
6 · The paper itself

Abstract

Sex differences are present in psychiatric disorders associated with disrupted dopamine function, and thus, sex differences in dopamine neurobiology may underlie these clinical disparities. In this chapter, we review sex differences in the dopaminergic system with a focus on substance use disorders, especially tobacco smoking, as our exemplar disorder. This chapter is organized into five sections describing sex differences in the dopaminergic system: (1) neurobiology, (2) role of sex hormones, (3) genetic underpinnings, (4) cognitive function, and (5) influence on addiction. In each section, we provide an overview of the topic area, summarize sex differences identified to date, highlight addiction research, especially clinical neuroimaging studies, and suggest avenues for future research.

Indexed as

Behavior, AddictiveSubstance-Related DisordersDopamineFemaleHumansMaleNeurobiologyNeuroimagingDopamineDopamineDrug addictionHormonesSex differencesTobacco smoking

Identifiers

PMID33008522
PMCPMC11267480
OpenAlexW3089746976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.