Evidence map›Paper›PMID 33008494›Full record

ReviewThe Urologic clinics of North America2020

Harnessing Natural Killer Cell Function for Genitourinary Cancers.

Nina Bhardwaj, Adam M Farkas, Zeynep Gul, John P Sfakianos

Open access · greenAbstract readReview
In one paragraph

Review in The Urologic clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Observational
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nina BhardwajDepartment of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, Hess CSM Building 1470 Madison Avenue, New York, NY 10029, USA. Electronic address: Nina.Bhardwaj@mssm.edu.
Adam M FarkasDepartment of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, 1470 Madison Avenue, New York, NY 10029, USA.
Zeynep GulDepartment of Urology, Icahn School of Medicine at Mount Sinai, Icahn Building, 1425 Madison Avenue, New York, NY 10029, USA.
John P SfakianosDepartment of Urology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1272, New York, NY 10029, USA.
Icahn School of Medicine at Mount Sinai · USTisch Cancer Institute

Funding

Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancerR01CA249175 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BHARDWAJ, NINA, GALSKY, MATTHEW · 2020 to 2024
$3.5M
NK cell exhaustion in metastatic melanomaR01CA201189 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BHARDWAJ, NINA · 2016 to 2020
$2.1M
NCI NIH HHS R01 CA201189NCI NIH HHS R01 CA249175
6 · The paper itself

Abstract

Natural killer (NK) cells are potently cytolytic innate lymphocytes involved in the immune surveillance of tumors and virally infected cells. Although much progress has been made in manipulating the ability of T cells to recognize and eliminate tumors, a comprehensive understanding of NK-cell infiltration into solid tumors, and their amenability to immunomodulation, remains incomplete. This article discusses recent studies showing that urologic tumors are infiltrated by NK cells and that these NK cells are often dysfunctional, but that strategies interfering with inhibitory axes have significant potential to alleviate this dysfunction.

Indexed as

Biological TherapyFemaleHumansImmunity, InnateImmunotherapyKidney NeoplasmsKiller Cells, NaturalMaleMolecular Targeted TherapyProstatic NeoplasmsRisk AssessmentTreatment OutcomeUrinary Bladder NeoplasmsUrogenital NeoplasmsBladder cancerGenitourinary cancerImmunotherapyNatural killer cellsNK cellsRCCRenal cancer

Identifiers

PMID33008494
PMCPMC7992041
OpenAlexW3082437950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.