Trial reportBritish medical journal (Clinical research ed.)1987
Controlled trial of long term oral potassium supplements in patients with mild hypertension.
Trial report in British medical journal (Clinical research ed.), 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Potassium Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials.Journal of the American Heart Association · 2020Pooled it
- Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials.PloS one · 2017Pooled it
- Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses.BMJ (Clinical research ed.) · 2013Pooled it
- Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV.Journal of human hypertension · 2004Guideline
- Lifestyle modifications to prevent and control hypertension. 6. Recommendations on potassium, magnesium and calcium. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Health Canada, Heart and Stroke Foundation of Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1999Guideline
- Difensil Immuno Reduces Recurrence and Severity of Tonsillitis in Children: A Randomized Controlled Trial.Nutrients · 2020Trial
- Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis.Journal of human hypertension · 2013Trial
- Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials.Journal of human hypertension · 2003Trial
- Efficacy of potassium and magnesium in essential hypertension: a double-blind, placebo controlled, crossover study.BMJ (Clinical research ed.) · 1990Trial
- Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension.Clinical science (London, England : 1979) · 2022Article
- Associations between serum potassium and sodium levels and risk of hypertension: a community-based cohort study.Journal of geriatric cardiology : JGC · 2015Article
- Non-pharmacological aspects of blood pressure management: what are the data?Kidney international · 2011Review
- Role of diet in hypertension management.Current hypertension reports · 2006Review
- Dietary electrolytes and hypertension in the elderly.International urology and nephrology · 2001Review
- Cost-effective intervention in stroke.PharmacoEconomics · 1992Review
- Citrate and recurrent idiopathic calcium urolithiasis. A longitudinal pilot study on the metabolic effects of oral potassium citrate administered over the short-, medium- and long-term medication of male stone patients.Urological research · 1992Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 15 week randomised double blind placebo controlled trial of oral potassium supplements (48 mmol daily) was conducted in 37 patients who had mildly increased blood pressure and a normal dietary intake of sodium. After a two month run in and a one week baseline period the patients were randomly assigned to receive either potassium supplements (n = 18) or placebo (n = 19). By the third week of treatment blood pressure in the actively treated group had decreased significantly compared with that in the placebo group, though the decrease reached its maximum after 15 weeks. Urinary potassium excretion increased significantly in the group who received potassium supplements, but no significant changes were found in plasma sodium and potassium concentrations or in urinary sodium excretion. In a subgroup of 13 patients who underwent a further nine weeks of treatment with oral potassium supplements at half of the previous dose (24 mmol daily) their blood pressure, at the end of this second study period, was still significantly lower compared with their baseline value but not with that of the placebo group. These results show that moderate oral potassium supplements are associated with a long term reduction in blood pressure in patients who have mild hypertension.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.