ArticleMicrobial cell factories2020
MsrR is a thiol-based oxidation-sensing regulator of the XRE family that modulates C. glutamicum oxidative stress resistance.
Article in Microbial cell factories, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 23 citations in OpenAlex.
- An XRE-type regulator inMicrobiology spectrum · 2026Article
- Functional Identification of AcsR, a MarR Family Transcriptional Regulator Involved in the Regulation of Aromatic Compound-Degrading Genes inMicroorganisms · 2026Article
- Putative membrane protein Cgl2168 and its variant enhance thermotolerance inSynthetic and systems biotechnology · 2026Article
- Xtr-mediated regulation of 4Fe-4S binding protein gene confers resistance to oxidative and antibiotic stress inFrontiers in microbiology · 2026Article
- Computational-Experimental Identification of Palindromic Motifs Bound by Bacterial XRE Family Transcriptional Regulators.Life (Basel, Switzerland) · 2025Article
- Evaluation of Differentially Expressed Candidate Genes in Benzo[a]pyrene Degradation by Burkholderia vietnamiensis G4.Molecular biotechnology · 2025Article
- Genomic analysis of3 Biotech · 2025Article
- Comprehensive network of stress-induced responses in Zymomonas mobilis during bioethanol production: from physiological and molecular responses to the effects of system metabolic engineering.Microbial cell factories · 2024Review
- XRE transcription factors conserved in Caulobacter and φCbK modulate adhesin development and phage production.PLoS genetics · 2023Article
- The flavohaemoprotein hmp maintains redox homeostasis in response to reactive oxygen and nitrogen species in Corynebacterium glutamicum.Microbial cell factories · 2023Article
- Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Effect of NaCl stress on exoproteome profiles ofFrontiers in microbiology · 2023Article
- A Novel XRE-Type Regulator Mediates Phage Lytic Development and Multiple Host Metabolic Processes in Pseudomonas aeruginosa.Microbiology spectrum · 2022Article
- Base editor enables rational genome-scale functional screening for enhanced industrial phenotypes inScience advances · 2022Article
- Screening for Virulence-Related Genes via a Transposon Mutant Library ofMicroorganisms · 2022Article
- XRE family transcriptional regulator XtrSs modulates Streptococcus suis fitness under hydrogen peroxide stress.Archives of microbiology · 2022Article
- OsnR is an autoregulatory negative transcription factor controlling redox-dependent stress responses in Corynebacterium glutamicum.Microbial cell factories · 2021Article
- Comparison of transcriptional profiles of Treponema pallidum during experimental infection of rabbits and in vitro culture: Highly similar, yet different.PLoS pathogens · 2021Article
- Genomics Characterization of an EngineeredFrontiers in bioengineering and biotechnology · 2021Article
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7 authors at 2 institutions in 1 country.
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Abstract
backgroundCorynebacterium glutamicum thrives under oxidative stress caused by the inevitably extreme environment during fermentation as it harbors antioxidative stress genes. Antioxidant genes are controlled by pathway-specific sensors that act in response to growth conditions. Although many families of oxidation-sensing regulators in C. glutamicum have been well described, members of the xenobiotic-response element (XRE) family, involved in oxidative stress, remain elusive.
resultsIn this study, we report a novel redox-sensitive member of the XER family, MsrR (multiple stress resistance regulator). MsrR is encoded as part of the msrR-3-mst (3-mercaptopyruvate sulfurtransferase) operon; msrR-3-mst is divergent from multidrug efflux protein MFS. MsrR was demonstrated to bind to the intergenic region between msrR-3-mst and mfs. This binding was prevented by an MsrR oxidation-mediated increase in MsrR dimerization. MsrR was shown to use Cys62 oxidation to sense oxidative stress, resulting in its dissociation from the promoter. Elevated expression of msrR-3-mst and mfs was observed under stress. Furthermore, a ΔmsrR mutant strain displayed significantly enhanced growth, while the growth of strains lacking either 3-mst or mfs was significantly inhibited under stress.
conclusionThis report is the first to demonstrate the critical role of MsrR-3-MST-MFS in bacterial stress resistance.
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