Evidence map›Paper›PMID 33008382›Full record

ArticleBMC surgery2020

Clinical significance of peripheral blood-derived inflammation markers in advanced gastric cancer after radical resection.

Lihu Gu, Mian Wang, Xuena Cui, Jiahang Mo, Lingling Yuan, Feiyan Mao, Kang Zhang, Derry Minyao Ng, Ping Chen, Dongjie Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lihu GuDepartment of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
Mian WangInfection Department, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, China.
Xuena CuiIntensive Care Unit, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, China.
Jiahang MoThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Lingling YuanDepartment of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
Feiyan MaoDepartment of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
Kang ZhangMedical College of Ningbo University, Ningbo, Zhejiang, China.
Derry Minyao NgMedical College of Ningbo University, Ningbo, Zhejiang, China.
Ping ChenDepartment of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.
Dongjie WangDepartment of Clinical Laboratory, HwaMei Hospital, University of Chinese Academy of Sciences, Northwest Street 41, Haishu District, Ningbo, 315010, Zhejiang, China. 0574wdj@sina.com.ORCID http://orcid.org/0000-0003-0501-1203

Funding

Ningbo Clinical Research Center for Digestive System Tumors 2019A21003Oncology Key Special Subject of Ningbo 2016-55the Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province 2019E10020
6 · The paper itself

Abstract

backgroundThe prognostic significance of peripheral blood-derived inflammation markers in patients with gastric cancer (GC) has not been elucidated. This study aimed to investigate the relationship between systemic inflammatory markers and GC prognosis.

methodsA prospective observational cohort study involving 598 patients was conducted to analyze the prognosis of GC based on systemic inflammatory markers. The following peripheral blood-derived inflammation markers were evaluated: the neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune-inflammation index (SII), C-reactive protein/albumin (CRP/Alb) ratio, Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), prognostic nutrition index (PNI), and prognostic index (PI). The receiver operating characteristics (ROC) curve and the Youden index were used to determine the optimal cutoff values. Univariate and multivariate analysis of prognostic factors was conducted accordingly.

resultsThe optimal cutoff values of the PNI, fibrinogen, NLR, PLR, SII, and CRP/Alb were 49.5, 397 ng/dl, 2.5, 154, 556, and 0.05, respectively. Multivariate analysis showed that age, PLR, TNM stage, and chemotherapy were the independent prognostic factors for advanced gastric cancer (AGC). Adjuvant chemotherapy improved the long-term prognosis of patients with PLR ≥154, but chemotherapy had no significant effect on the survival of patients with PLR < 154.

conclusionsOur findings show that higher PLR (≥154) is an independent risk factor for poor prognosis in GC patients. Besides, PLR can predict adjuvant chemotherapy (oxaliplatin/5-fluorouracil combination) response in patients with GC after surgery.

Indexed as

BiomarkersCohort StudiesFemaleHumansInflammationLymphocytesMaleNeutrophilsPrognosisProspective StudiesRetrospective StudiesStomach NeoplasmsBiomarkersChemotherapyGastric cancerPlatelet lymphocyte ratioPrognosisSystemic inflammatory marker

Identifiers

PMID33008382
PMCPMC7532590

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.