ArticleBMC pulmonary medicine2020
The fraction of sensitization among lung transplant recipients in a transplant center in Japan.
Article in BMC pulmonary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Long-term survival and clinical outcomes of delayed chest closure following lung transplantation.Surgery today · 2024Article
- Thoracic and vertebral deformities in lung transplantation: perioperative complications and long-term prognoses.BMC pulmonary medicine · 2024Article
- COVID-19 pneumonia in lung transplant recipients: understanding risk factors and treatment outcomes in Japan.Clinical and experimental medicine · 2024Article
- Native-lung complications following single-lung transplantation for interstitial lung disease: an in-depth analysis.BMC pulmonary medicine · 2024Article
- Letermovir prophylaxis for cytomegalovirus in lung-transplant recipients: a comprehensive study with literature review of off-label use and real-world experiences.Clinical and experimental medicine · 2024Review
- Roles of respirologists in lung transplantation in Japan: narrative review.Journal of thoracic disease · 2023Review
- Assessment of Anti-Human Leukocyte Antigen (HLA)-Antibody-Dependent Humoral Response in Patients before and after Lung Transplantation.Medicina (Kaunas, Lithuania) · 2022Article
- Efficacy and safety of mRNA SARS-CoV-2 vaccines in lung transplant recipients.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Article
- Outcome and prognostic factors after lung transplantation for bronchiectasis other than cystic fibrosis.BMC pulmonary medicine · 2021Article
- Recovery of physical function in lung transplant recipients with sarcopenia.BMC pulmonary medicine · 2021Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAnti-human leukocyte antigen (HLA) antibody testing was approved by the Japanese government in 2018. As such, there was no longitudinal data regarding the HLA-sensitization of lung transplant (LTX) patients in Japan. We therefore set out to measure anti-HLA antibodies from all our LTX patients during their annual follow-up to characterize the sensitization status in the Japanese population.
methodsThe cross-sectional study was conducted for consecutive LTX recipients who underwent transplantation from January 2000 to January 2020 at Tohoku University Hospital (TUH). The serum from the recipients was screened for anti-HLA antibody with the panel-reactive assay (PRA) and the donor-specific antibodies (DSA).
resultsSensitization was reviewed in 93 LTX recipients, showing 23 positive (24.7%) and 70 negative (75.3%) PRA. More sensitized recipients were found in recent transplantations (60.9% (14/23), ≤5 years post LTX) than in older transplantations (17.4% (4/23), 5-10 years or 21.7% (5/23), ≥10 years post LTX) (p = 0.04). Even fewer recipients had DSA (5.4%, 5/93), among whom 4/5 (80%) were recently transplanted.
conclusionThe rate of PRA positive LTX recipients in our population was lower compared with those in previous reports from US and Europe. More sensitized LTRs were found in recent transplantations than the older cohort, and DSA was identified primarily in the recent recipients. Due to several limitations, it is still unclear whether the sensitization would be related the development of CLAD or survival, yet this study would be fundamental to the future anti-HLA body study in Japanese population.
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