Evidence map›Paper›PMID 33008307›Full record

ArticleBMC geriatrics2020

Kidney function and other factors and their association with falls : The screening for CKD among older people across Europe (SCOPE) study.

Sabine Britting, Rada Artzi-Medvedik, Paolo Fabbietti, Lisanne Tap, Francesco Mattace-Raso, Andrea Corsonello, Fabrizia Lattanzio, Johan Ärnlöv, Axel C Carlsson, Regina Roller-Wirnsberger and 11 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
In one paragraph

Article in BMC geriatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02691546 (Screening for Chronic Kidney Disease), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02691546 completednot on this map

Screening for Chronic Kidney Disease (CKD) Among Older People Across Europe (SCOPE)

TypeobservationalSponsorIstituto Nazionale di Ricovero e Cura per AnzianiRan2016 to 2020Enrolled2,434ConditionsChronic Kidney DiseasesArmsblood sample collection
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Insights into Cognitive Brain Health in Chronic Kidney Disease.Gerontology & geriatrics : research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 8 countries.

Sabine BrittingDepartment of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Rada Artzi-MedvedikDepartment of Nursing, Recanati School for Community Health Professions at the faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
Paolo FabbiettiItalian National Research Center on Aging (IRCCS INRCA), Fermo and Cosenza, Ancona, Italy. p.fabbietti@inrca.it.ORCID 0000-0003-2130-3070
Lisanne TapDepartment of Internal Medicine, Section of Geriatric Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Francesco Mattace-RasoDepartment of Internal Medicine, Section of Geriatric Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Andrea CorsonelloItalian National Research Center on Aging (IRCCS INRCA), Fermo and Cosenza, Ancona, Italy.
Fabrizia LattanzioItalian National Research Center on Aging (IRCCS INRCA), Fermo and Cosenza, Ancona, Italy.
Johan ÄrnlövDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Axel C CarlssonDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Regina Roller-WirnsbergerDepartment of Internal Medicine-Geriatrics, Medical University of Graz, Graz, Austria.
Gerhard WirnsbergerDivision of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Tomasz KostkaDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Lodz, Poland.
Agnieszka GuligowskaDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Lodz, Poland.
Francesc FormigaGeriatric Unit, Internal Medicine Department, Bellvitge University Hospital - IDIBELL - L'Hospitalet de Llobregat, Barcelona, Spain.
Rafael Moreno-GonzalezGeriatric Unit, Internal Medicine Department, Bellvitge University Hospital - IDIBELL - L'Hospitalet de Llobregat, Barcelona, Spain.
Pedro GilGeriatric Department, Hospital Clínico San Carlos, Martín Lagos S/N, 28040, Madrid, Spain.
Sara Lainez MartinezGeriatric Department, Hospital Clínico San Carlos, Martín Lagos S/N, 28040, Madrid, Spain.
Robert KobDepartment of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Itshak MelzerDepartment of Physical Therapy, Recanati School for Community Health Professions at the faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
Ellen FreibergerDepartment of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
SCOPE investigators
Istituto Nazionale di Riposo e Cura per Anziani · ITBellvitge University Hospital · ESErasmus MC · NLFriedrich-Alexander-Universität Erlangen-Nürnberg · DEBen-Gurion University of the Negev · ILHospital Clínico San Carlos · ESMedical University of Graz · ATMedical University of Lodz · PLDalarna University · SEIstituti di Ricovero e Cura a Carattere Scientifico · ITUppsala University · SE

Funding

Horizon 2020 Framework Programme 634869
6 · The paper itself

Abstract

backgroundReduced kidney function has become a major public health concern, especially among older people, as Chronic Kidney Disease (CKD) is associated with increased risk of end stage renal disease and mortality. Falls are a serious negative health outcome in older persons with one third of people aged 65 years experiencing a fall per year and increasing fall rates with increasing age. The impact of CKD on falls in older community-dwelling persons is not well investigated. Additionally, lower urinary tract symptoms (LUTS) may also increase the risk of falls. Therefore, our aim was to investigate the impact of CKD and LUTS on falls as well as on injurious falls.

methodsThe SCOPE study is an observational, multinational, multicenter, prospective cohort study involving community-dwelling older persons aged 75 years and more recruited from August 2016 to March 2018 in seven European countries. The main outcomes of the present study were any falls and any injurious falls during the 12 months before enrolment. The cross-sectional association of estimated glomerular filtration rate (eGFR) and LUTS with study outcomes was investigated by logistic regression analysis adjusted for baseline characteristics of enrolled subjects.

resultsOur series consisted of 2256 SCOPE participants (median age = 79.5 years, 55.7% female). Of them, 746 participants experienced a fall and 484 reported an injurious fall in the 12 months prior to baseline assessment. CKD was not significantly associated with falls (OR = 0.95, 95%CI = 0.79-1.14 for eGFR< 60; OR = 1.02, 95%CI = 0.81-1.28 for eGFR< 45; OR = 1.08, 95%CI = 0.74-1.57 for eGFR< 30) or injurious falls (OR = 0.91, 95%CI = 0.67-1.24 for eGFR< 60; OR = 0.93, 95%CI = 0.63-1.37 for eGFR< 45; OR = 1.19, 95%CI = 0.62-2.29 for eGFR< 30). LUTS were found significantly associated with both falls (OR = 1.56, 95%CI = 1.29-1.89) and injurious falls (OR = 1.58, 95%CI = 1.14-2.19), and such associations were confirmed in all multivariable models.

conclusionsCross-sectional data suggest that CKD may not be associated with history of falls or injurious falls, whereas LUTS is significantly associated with the outcomes.

trial registrationThis study was registered on 25th February 2016 at clinicaltrials.gov ( NCT02691546 ).

Indexed as

Activities of Daily LivingRenal Insufficiency, ChronicAgedAged, 80 and overCross-Sectional StudiesEuropeFearFemaleHumansKidneyMaleProspective StudiesRetrospective StudiesFallsFear of fallingInjurious fallsKidney functionOlder peopleUrinary incontinence

Identifiers

PMID33008307
PMCPMC7531089
OpenAlexW3089986619

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.