Evidence map›Paper›PMID 33008099›Full record

ArticleInternational journal of molecular sciences2020

Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.

Soon-Young Kim, Eun-Hye Lee, Eun Na Kim, Woo-Chan Son, Yeo Hyang Kim, Seung-Yoon Park, In-San Kim, Jung-Eun Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Reduction ofFrontiers in cardiovascular medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Soon-Young KimDepartment of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Eun-Hye LeeDepartment of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Eun Na KimDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Woo-Chan SonDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Yeo Hyang KimDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0002-1631-574X
Seung-Yoon ParkDepartment of Biochemistry, School of Medicine, Dongguk University, Gyeongju 38066, Korea.
In-San KimCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.
Jung-Eun KimDepartment of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Kyungpook National University · KRUlsan College · KRDongguk University · KRKorea University · KRKyungpook National University Hospital · KR

Funding

National Research Foundation of Korea 2016R1A2B4010043, 2019R1A2C1003398
6 · The paper itself

Abstract

The placenta undergoes reconstruction at different times during fetal development to supply oxygen and nutrients required throughout pregnancy. To accommodate the rapid growth of the fetus, small spiral arteries undergo remodeling in the placenta. This remodeling includes apoptosis of endothelial cells that line spiral arteries, which are replaced by trophoblasts of fetal origin. Removal of dead cells is critical during this process. Stabilin-1 (Stab1) and stabilin-2 (Stab2) are important receptors expressed on scavenger cells that absorb and degrade apoptotic cells, and Stab1 is expressed in specific cells of the placenta. However, the role of Stab1 and Stab2 in placental development and maintenance remain unclear. In this study, we assessed Stab1 and Stab2 expression in the placenta and examined the reproductive capacity and placental development using a double-knockout mouse strain lacking both Stab1 and Stab2 (Stab1/2 dKO mice). Most pregnant Stab1/2 dKO female mice did not produce offspring and exhibited placental defects, including decidual hemorrhage and necrosis. Findings of this study offer the first description of the phenotypic characteristics of placentas and embryos of Stab1/2 dKO females during pregnancy, suggesting that Stab1 and Stab2 are involved in placental development and maintenance.

Indexed as

AnimalsCell Adhesion Molecules, NeuronalEndothelial CellsFemaleFetal DevelopmentHumansMiceMice, KnockoutOxygenPlacentaPlacentationPregnancyReproductionTrophoblastsVascular RemodelingCell Adhesion Molecules, NeuronalOxygenStab1 protein, mouseStab2 protein, mousedeciduadouble knockouthemorrhageplacentaStabilin-1Stabilin-2

Identifiers

PMID33008099
PMCPMC7583024
OpenAlexW3090410987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.