Evidence map›Paper›PMID 33008001›Full record

ArticleMolecules (Basel, Switzerland)2020

Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study.

Inbar Schlachet, Hen Moshe Halamish, Alejandro Sosnik

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Inbar SchlachetLaboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.
Hen Moshe HalamishLaboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.
Alejandro SosnikLaboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.ORCID 0000-0003-4704-4599
Technion – Israel Institute of Technology · IL

Funding

Israel Science Foundation 269/15
6 · The paper itself

Abstract

Intranasal (i.n.) administration became an alternative strategy to bypass the blood-brain barrier and improve drug bioavailability in the brain. The main goal of this work was to preliminarily study the biodistribution of mixed amphiphilic mucoadhesive nanoparticles made of chitosan-

Indexed as

Drug Delivery SystemsAdministration, IntranasalAnimalsArea Under CurveBrainChitosanCross-Linking ReagentsFluorescenceMiceNanoparticlesPolymethyl MethacrylatePolyvinyl AlcoholSurface-Active AgentsTissue DistributionChitosanCross-Linking ReagentsPolymethyl MethacrylatePolyvinyl AlcoholSurface-Active Agentsbiodistributionblood–brain barrier (BBB)central nervous system (CNS)intranasal deliveryself-assembled polymeric nanoparticles

Identifiers

PMID33008001
PMCPMC7582691
OpenAlexW3089323500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.