Evidence map›Paper›PMID 33007994›Full record

ArticleLife (Basel, Switzerland)2020

ITRAQ Proteomic Analysis of Yellow and Black Skin in Jinbian Carp (

Xiangchen Ye, Lingling Zhou, Jingyi Jia, Lingjing Wei, Yanhong Wen, Xueyu Yan, Jie Huang, Baojiang Gan, Kang Liu, Yejian Lv and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiangchen YeAquatic Species Introduction and Breeding Center of Guangxi, Nanning 530031, China.
Lingling ZhouCollege of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
Jingyi JiaCollege of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
Lingjing WeiAquatic Species Introduction and Breeding Center of Guangxi, Nanning 530031, China.
Yanhong WenExtension Station of Fisheries Technology of Liuzhou, Liuzhou 545006, China.
Xueyu YanAquatic Species Introduction and Breeding Center of Guangxi, Nanning 530031, China.
Jie HuangExtension Station of Fisheries Technology of Liuzhou, Liuzhou 545006, China.
Baojiang GanAquatic Species Introduction and Breeding Center of Guangxi, Nanning 530031, China.
Kang LiuAquatic Species Introduction and Breeding Center of Guangxi, Nanning 530031, China.
Yejian LvAquatic Species Introduction and Breeding Center of Guangxi, Nanning 530031, China.
Guangfu HuCollege of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0003-3000-1920
Guangxi Academy of Fishery Sciences · CNHuazhong Agricultural University · CN

Funding

China Agriculture Research System CARS-45Fundamental Research Funds for the Central Universities 2662019PY006
6 · The paper itself

Abstract

Colors are important phenotypic traits for fitness under natural conditions in vertebrates. Previous studies have reported several functional genes and genetic variations of pigmentation, but the formation mechanisms of various skin coloration remained ambiguous in fish. Jinbian carp, a common carp variant, displays two colors (yellow and black) in the skin, thus, it is a good model for investigating the genetic basis of pigmentation. In the present study, using the Jinbian carp as model, isobaric tags for relative and absolute quantification (ITRAQ) proteomics analysis was performed for yellow and black skin, respectively. The results showed that 467 differentially expressed proteins (DEPs) were identified between the yellow skin and the black skin. Similar to mammals, the up-regulated DEPs in black skin included UV excision repair protein RAD23 homolog A (Rad23a), melanoregulin (mreg), 5,6-dihydroxyindole-2-carboxylic acid oxidase5 (tyrp1) and melanocyte protein PMEL (PMEL), which were mainly grouped into melanogenesis pathway. However, several up-regulated DEPs in yellow skin were mainly enriched in nucleotide metabolism, such as GTPase IMAP family member 5 (GIMAP5), AMP deaminase 1 (AMPD1), adenosylhomocysteinase b (ahcy-b), and pyruvate kinase (PKM). In summary, several candidate proteins and their enrichment pathways for color variation in Jinbian carp were identified, which may be responsible for the formation of different colorations.

Indexed as

ITRAQJinbian carpmelaninpigmentationpteridine

Identifiers

PMID33007994
PMCPMC7601221
OpenAlexW3090652723

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.