Evidence map›Paper›PMID 33007987›Full record

ArticleGenes2020

Application of CRISPR/Cas9-Based Reverse Genetics in

Vanessa Adaui, Constanze Kröber-Boncardo, Christine Brinker, Henner Zirpel, Julie Sellau, Jorge Arévalo, Jean-Claude Dujardin, Joachim Clos

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Live attenuated-nonpathogenicFrontiers in microbiology · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Targeted Deletion of Centrin inFrontiers in cellular and infection microbiology · 2021
    Article
  11. Effective Genome Editing inFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Vanessa AdauiBernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.ORCID 0000-0001-8516-006X
Constanze Kröber-BoncardoBernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Christine BrinkerBernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Henner ZirpelBernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Julie SellauBernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.
Jorge ArévaloInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Jean-Claude DujardinCentre for Research and Innovation, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15067, Peru.ORCID 0000-0002-9217-5240
Joachim ClosBernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.ORCID 0000-0003-4377-8173
Bernhard Nocht Institute for Tropical Medicine · DECity Of Hope National Medical Center · USPeruvian University of Applied Sciences · PEUniversidad Peruana Cayetano Heredia · PEUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The protozoan parasite

Indexed as

CRISPR-Cas SystemsReverse GeneticsEndopeptidase ClpGene EditingGenes, ProtozoanGene TargetingHeat-Shock ProteinsLeishmania braziliensisLeishmania majorMutationPolymerase Chain ReactionProtozoan ProteinsThermotoleranceClpB protein, LeishmaniaEndopeptidase ClpHeat-Shock ProteinsProtozoan ProteinsCRISPR–Cas9gene targetingheat shock proteinsLeishmania braziliensisphenotypingreverse genetics

Identifiers

PMID33007987
PMCPMC7601497
OpenAlexW3091038366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.