Evidence map›Paper›PMID 33007939›Full record

ArticleInternational journal of environmental research and public health2020

Gestational Pesticide Exposure and Child Respiratory Health.

Robyn Gilden, Erika Friedmann, Katie Holmes, Kimberly Yolton, Yingying Xu, Bruce Lanphear, Aimin Chen, Joseph Braun, Adam Spanier

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. The association between prenatal pyrethroids exposure and children's health - current research.International journal of occupational medicine and environmental health · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Effect of Gestational Pesticide Exposure on the Child's Respiratory System: A Narrative Review.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Robyn GildenDepartment of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Erika FriedmannOffice of Research and Scholarship, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Katie HolmesOffice of Research and Scholarship, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Yingying XuDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Bruce LanphearDepartment of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0001-9713-6438
Joseph BraunDepartment of Epidemiology, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-5239-3235
Adam SpanierDepartment of Pediatrics, Division of General Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-3108-3809
University of Maryland, Baltimore · USCincinnati Children's Hospital Medical Center · USBrown University · USSimon Fraser University · CAUniversity of Pennsylvania · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
Developmental neurotoxicity of organophosphate and novel brominated flame retardants in childrenR01ES028277 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2017 to 2022
$3.4M
A Community-Based Trial to Prevent Lead Poisoning and InjuriesR01ES014575 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI YOLTON, KIMBERLY · 2007 to 2011
$2.9M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
Endocrine Disrupting Chemicals, Thyroid Hormones, and Child NeurobehaviorR01ES024381 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2015 to 2018
$2.4M
Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early ChildhoodR01ES015517 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI YOLTON, KIMBERLY · 2009 to 2010
$1.5M
NIEHS NIH HHS P01 ES011261NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES014575NIEHS NIH HHS R01 ES015517NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES024381NIEHS NIH HHS R01 ES028277
6 · The paper itself

Abstract

backgroundChildhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase;

methodsWe analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (OP) and pyrethroid (3PBA) metabolite concentrations with child wheeze, forced expiratory volume in one second (FEV1) at ages 4 and 5 years, and wheeze trajectory patterns through age 8 years.

resultsAmong 367 singletons, the frequency of wheeze ranged from 10.6% to 24.1% at each measurement age. OP and 3PBA metabolite concentrations were not associated with wheeze at 8 years or from birth to 8 years, but there were three significant interactions: (1) maternal daily fruit and vegetable consumption (less than daily consumption and increasing 3PBA was associated with wheeze at age 8 years, OR = 1.40), (2) maternal

conclusionsGestational OP and 3PBA metabolites were associated with child respiratory outcomes in participants with maternal dietary and genetic susceptibility.

Indexed as

Maternal ExposurePesticidesRespiratory SoundsRespiratory Tract DiseasesAryldialkylphosphataseChildChild, PreschoolFemaleHumansMaleOrganophosphatesOrganophosphorus CompoundsPregnancyProspective StudiesAryldialkylphosphataseOrganophosphatesOrganophosphorus CompoundsPesticidesPON1 protein, humanchildrengestational exposureorganophosphatespyrethroidswheeze

Identifiers

PMID33007939
PMCPMC7579149
OpenAlexW3091763983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.