Evidence map›Paper›PMID 33007887›Full record

ArticleMolecules (Basel, Switzerland)2020

A Novel Series of [1,2,4]Triazolo[4,3-a]Pyridine Sulfonamides as Potential Antimalarial Agents: In Silico Studies, Synthesis and In Vitro Evaluation.

Veronika R Karpina, Svitlana S Kovalenko, Sergiy M Kovalenko, Oleksandr G Drushlyak, Natalya D Bunyatyan, Victoriya A Georgiyants, Vladimir V Ivanov, Thierry Langer, Louis Maes

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Veronika R KarpinaDepartment of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska str., 61002 Kharkiv, Ukraine.ORCID 0000-0002-6589-0337
Svitlana S KovalenkoDepartment of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska str., 61002 Kharkiv, Ukraine.
Sergiy M KovalenkoDepartment of Organic Chemistry, V.N. Karazin Kharkiv National University, 4 Svobody Sq., 61022 Kharkiv, Ukraine.ORCID 0000-0003-2222-8180
Oleksandr G DrushlyakDepartment of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska str., 61002 Kharkiv, Ukraine.
Natalya D BunyatyanFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8-2 Trubetskaya str., Moscow 119991, Russia.
Victoriya A GeorgiyantsDepartment of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska str., 61002 Kharkiv, Ukraine.ORCID 0000-0001-8794-8010
Vladimir V IvanovDepartment of Organic Chemistry, V.N. Karazin Kharkiv National University, 4 Svobody Sq., 61022 Kharkiv, Ukraine.ORCID 0000-0003-2297-9048
Thierry LangerDepartment of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria.
Louis MaesLaboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.ORCID 0000-0002-2324-9509

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For the development of new and potent antimalarial drugs, we designed the virtual library with three points of randomization of novel [1,2,4]triazolo[4,3-

Indexed as

Computer SimulationAntimalarialsBinding SitesCell LineDrug Evaluation, PreclinicalHumansLigandsMolecular Docking SimulationPlasmodium falciparumPyridinesSulfonamidesTriazolesAntimalarialsLigandsPyridinespyridine sulfonamideSulfonamidesTriazoles[1,2,4]triazolo[4,3-a]pyridinesantimalarialfalcipain-2molecular dockingPlasmodium falciparumsulfonamidevirtual screening

Identifiers

PMID33007887
PMCPMC7582516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.