Evidence map›Paper›PMID 33007815›Full record

ArticleCancers2020

A Machine-Learning Tool Concurrently Models Single Omics and Phenome Data for Functional Subtyping and Personalized Cancer Medicine.

Gift Nyamundanda, Katherine Eason, Justin Guinney, Christopher J Lord, Anguraj Sadanandam

Abstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gift NyamundandaDivision of Molecular Pathology, The Institute of Cancer Research, London SW3 6JB, UK.
Katherine EasonDivision of Molecular Pathology, The Institute of Cancer Research, London SW3 6JB, UK.
Justin GuinneySage Bionetworks, Seattle, WA 98121, USA.
Christopher J LordThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Anguraj SadanandamDivision of Molecular Pathology, The Institute of Cancer Research, London SW3 6JB, UK.

Funding

Cancer Research UK 14276Cancer Research UK 24439
6 · The paper itself

Abstract

One of the major challenges in defining clinically-relevant and less heterogeneous tumor subtypes is assigning biological and/or clinical interpretations to etiological (intrinsic) subtypes. Conventional clustering/subtyping approaches often fail to define such subtypes, as they involve several discrete steps. Here we demonstrate a unique machine-learning method, phenotype mapping (

Indexed as

breast cancerCDK inhibitorcontinuous subtypesdimension reduction methodsetoposidefunctional subtypesgenome-phenome integrationmachine learningphenotypessubtyping

Identifiers

PMID33007815
PMCPMC7601761

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.