Evidence map›Paper›PMID 33007806›Full record

ReviewPharmaceutics2020

Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities.

Verônica da Silva Oliveira, Amanda Silva de Almeida, Ingrid da Silva Albuquerque, Fernanda Ílary Costa Duarte, Bárbara Cristina Silva Holanda Queiroz, Attilio Converti, Ádley Antonini Neves de Lima

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. The evaluation ofJournal of drug delivery science and technology · 2023
    Article
  3. Article
  4. Review
  5. Article
  6. Current Trends on Solid Dispersions: Past, Present, and Future.Advances in pharmacological and pharmaceutical sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Verônica da Silva OliveiraPostgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, Brazil.
Amanda Silva de AlmeidaDepartment of Pharmacy, Universidade Federal do Rio Grande do Norte, Natal-RN 59012-570, Brazil.
Ingrid da Silva AlbuquerqueDepartment of Pharmacy, Universidade Federal do Rio Grande do Norte, Natal-RN 59012-570, Brazil.
Fernanda Ílary Costa DuartePostgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, Brazil.
Bárbara Cristina Silva Holanda QueirozPostgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, Brazil.
Attilio ConvertiDepartment of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, Genoa University, I-16145 Genoa, Italy.ORCID 0000-0003-2488-6080
Ádley Antonini Neves de LimaPostgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, Brazil.ORCID 0000-0002-3798-3915

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliographic survey shows that the development of solid dispersions provides benefits in the physicochemical properties of bioactive compounds, which lead to an increase in their biological potential. However, despite the reports found on solid dispersions, there is still a need for biological assay-based studies, mainly in vivo, to assist in the investigation and to devise new applications. Therefore, studies based on such an approach are of great importance to enhance and extend the use of solid dispersions in the most diverse therapeutic applications.

Indexed as

biological applicationsdrug deliverysolid dispersions

Identifiers

PMID33007806
PMCPMC7601702

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.