Evidence map›Paper›PMID 33007669›Full record

ArticleTicks and tick-borne diseases2021

The sialotranscriptome of the gopher-tortoise tick, Amblyomma tuberculatum.

Shahid Karim, Deepak Kumar, Steve Adamson, Joshua R Ennen, Carl P Qualls, José M C Ribeiro

Open access · greenAbstract read
In one paragraph

Article in Ticks and tick-borne diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Serpins in the Spotlight: Novel Bioinformatic Insights IntoBiochemistry research international · 2025
    Article
  2. Article
  3. Review
  4. Review
  5. Arthropods and Fire Within the Biologically Diverse Longleaf Pine Ecosystem.Annals of the Entomological Society of America · 2022
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shahid KarimSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.
Deepak KumarSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.
Steve AdamsonSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.
Joshua R EnnenSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.
Carl P QuallsSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.
José M C RibeiroVector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12732 Twinbrook Parkway, Room 3E28, Rockville MD 20852, USA. Electronic address: jribeiro@niaid.nih.gov.
University of Southern Mississippi · USNational Institute of Allergy and Infectious Diseases · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
TOUGALOO PROTEOMICSP20RR016476 · NCRR · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI KRAMER, WOLFGANG · 2001 to 2011
$30.4M
Vector-Borne Diseases: Biology Of Vector Host RelationshipZIAAI000810 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RIBEIRO, JOSE · 2009 to 2025
$20.8M
Vector-Borne Diseases: Biology Of Vector Host RelationshipZ01AI000810 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI RIBEIRO, JOSE M · 1997 to 2008
$3.5M
Role of Vector antioxidant factors in Amblyomma-Rickettsia interactionR15AI099910 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI KARIM, SHAHID · 2012 to 2012
$440k
The Role of Hemocytes in tick Rickettsia parkeri infectionR21AI175885 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI KARIM, SHAHID · 2024 to 2025
$407k
Intramural NIH HHS Z01 AI000810NCRR NIH HHS P20 RR016476NIAID NIH HHS R15 AI099910NIAID NIH HHS R21 AI175885NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

The gopher tortoise tick, Amblyomma tuberculatum, is known to parasitize keystone ectotherm reptile species. The biological success of ticks requires precise mechanisms to evade host hemostatic and immune responses. Acquisition of a full blood meal requires attachment, establishment of the blood pool, and engorgement of the tick. Tick saliva contains molecules which counter the host responses to allow uninterrupted feeding on the host. RNASeq of the salivary glands of Amblyomma tuberculatum ticks were sequenced resulting in 138,030 pyrosequencing reads which were assembled into 29,991 contigs. A total of 1875 coding sequences were deduced from the transcriptome assembly, including 602 putative secretory and 982 putative housekeeping proteins. The annotated data sets are available as a hyperlinked spreadsheet. The sialotranscriptome assembled for this tick species made available a valuable resource for mining novel pharmacological activities and comparative analysis.

Indexed as

TranscriptomeAmblyommaAnimalsArthropod ProteinsFemaleRNA-SeqSalivary GlandsTurtlesArthropod ProteinsAmblyomma tuberculatumHematophagySalivary glandsSialomeTickTranscriptome

Identifiers

PMID33007669
PMCPMC7736221
OpenAlexW3087958078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.