Evidence map›Paper›PMID 33007634›Full record

ReviewCurrent opinion in biotechnology2020

Unraveling the mechanobiology of immune cells.

Xuexiang Zhang, Tae-Hyung Kim, Timothy J Thauland, Hongjun Li, Fatemeh Sadat Majedi, Chau Ly, Zhen Gu, Manish J Butte, Amy C Rowat, Song Li

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. TTNCell reports · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Xuexiang ZhangDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Tae-Hyung KimDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM 87106, USA.
Timothy J ThaulandDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California, Los Angeles, CA 90095, USA.
Hongjun LiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Fatemeh Sadat MajediDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Chau LyDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA.
Zhen GuDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Manish J ButteDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California, Los Angeles, CA 90095, USA.
Amy C RowatDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA.
Song LiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.

Funding

In Situ Regeneration of Blood VesselR01HL121450 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2015 to 2018
$1.8M
Influences of nanomechanical forces on T cellsR01GM110482 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTTE, MANISH J · 2014 to 2018
$1.6M
Therapeutic microneedles for localized treatment of periodontal tissueR56DE029157 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2019
$286k
NHLBI NIH HHS R01 HL121450NIDCR NIH HHS R56 DE029157NIGMS NIH HHS R01 GM110482
6 · The paper itself

Abstract

Immune cells can sense and respond to biophysical cues - from dynamic forces to spatial features - during their development, activation, differentiation and expansion. These biophysical signals regulate a variety of immune cell functions such as leukocyte extravasation, macrophage polarization, T cell selection and T cell activation. Recent studies have advanced our understanding on immune responses to biophysical cues and the underlying mechanisms of mechanotransduction, which provides rational basis for the design and development of immune-modulatory therapeutics. This review discusses the recent progress in mechanosensing and mechanotransduction of immune cells, particularly monocytes/macrophages and T lymphocytes, and features new biomaterial designs and biomedical devices that translate these findings into biomedical applications.

Indexed as

Biocompatible MaterialsMechanotransduction, CellularBiophysicsCell DifferentiationMacrophagesBiocompatible Materials

Identifiers

PMID33007634
PMCPMC7524653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.