Evidence map›Paper›PMID 33007615›Full record

ArticleBiosensors & bioelectronics2020

Array-based analysis of SARS-CoV-2, other coronaviruses, and influenza antibodies in convalescent COVID-19 patients.

Daniel J Steiner, John S Cognetti, Ethan P Luta, Alanna M Klose, Joseph Bucukovski, Michael R Bryan, Jon J Schmuke, Phuong Nguyen-Contant, Mark Y Sangster, David J Topham and 1 more

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Biosensors & bioelectronics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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  12. FRET-based hACE2 receptor mimic peptide conjugated nanoprobe for simple detection of SARS-CoV-2.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Daniel J SteinerBiochemistry and Biophysics, USA.
John S CognettiBiomedical Engineering, USA.
Ethan P LutaDermatology, USA.
Alanna M KloseDermatology, USA.
Joseph BucukovskiBiochemistry and Biophysics, USA.
Michael R BryanBiochemistry and Biophysics, USA.
Jon J SchmukeAdarza BioSystems, Inc., St. Louis, MO, 63146, USA.
Phuong Nguyen-ContantMicrobiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
Mark Y SangsterMicrobiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
David J TophamMicrobiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
Benjamin L MillerBiochemistry and Biophysics, USA; Biomedical Engineering, USA; Dermatology, USA. Electronic address: Benjamin_miller@urmc.rochester.edu.
University of Rochester · USAdarza BioSystems (United States) · US

Funding

NIAID NIH HHS HHSN272201400005C
6 · The paper itself

Abstract

Detection of antibodies to upper respiratory pathogens is critical to surveillance, assessment of the immune status of individuals, vaccine development, and basic biology. The urgent need for antibody detection tools has proven particularly acute in the COVID-19 era. We report a multiplex label-free antigen microarray on the Arrayed Imaging Reflectometry (AIR) platform for detection of antibodies to SARS-CoV-2, SARS-CoV-1, MERS, three circulating coronavirus strains (HKU1, 229E, OC43) and three strains of influenza. We find that the array is readily able to distinguish uninfected from convalescent COVID-19 subjects, and provides quantitative information about total Ig, as well as IgG- and IgM-specific responses.

Indexed as

Antibodies, ViralBetacoronavirusBiosensing TechniquesCoronavirusCoronavirus InfectionsCOVID-19Equipment DesignHEK293 CellsHumansInfluenza A virusInfluenza, HumanMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralProtein Array AnalysisSARS-CoV-2Antibodies, ViralAntigen microarrayCoronavirusInfluenza virusLabel-free biosensorSARS-CoV-2

Identifiers

PMID33007615
PMCPMC7522665
OpenAlexW3087397986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.