ArticleSeminars in arthritis and rheumatism2020
Occupation and risk of knee osteoarthritis and knee replacement: A longitudinal, multiple-cohort study.
Article in Seminars in arthritis and rheumatism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Association between physical activity and knee osteoarthritis: a comprehensive systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Recreational Physical Activity and Risk of Incident Knee Osteoarthritis: An International Meta-Analysis of Individual Participant-Level Data.Arthritis & rheumatology (Hoboken, N.J.) · 2022Pooled it
- Article
- Self-reported physical activity and risk of primary knee replacement for osteoarthritis: a competing risks cohort analysis.BMC musculoskeletal disorders · 2025Article
- Impact of meniscus injury and chondromalacia on the patient‑reported quality of life, social support, and mental health following knee arthroscopy.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025Article
- Associations between work characteristics and osteoarthritis: A cross-sectional study of 285,947 UK Biobank participants.Osteoarthritis and cartilage open · 2025Article
- Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside.Aging and disease · 2024Review
- Dynamic risk factors for complex regional pain syndrome after distal radius fracture surgery: multivariate analysis and prediction.BMC musculoskeletal disorders · 2024Article
- Association of neighborhood-level disadvantage beyond individual sociodemographic factors in patients with or at risk of knee osteoarthritis.BMC musculoskeletal disorders · 2024Article
- Assessing the Value of Imaging Data in Machine Learning Models to Predict Patient-Reported Outcome Measures in Knee Osteoarthritis Patients.Bioengineering (Basel, Switzerland) · 2024Article
- Current Evidence Using Pulsed Electromagnetic Fields in Osteoarthritis: A Systematic Review.Journal of clinical medicine · 2024Review
- Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study.Scientific reports · 2024Article
- Article
- Risk factors of knee osteoarthritis in Bangladeshi adults: a national survey.BMC musculoskeletal disorders · 2022Article
- Effect of Heeled Shoes on Joint Symptoms and Knee Osteoarthritis in Older Adults: A 5-Year Follow-Up Study.ACR open rheumatology · 2021Article
- Monitoring work-related physical activity and estimating lower-limb loading: a proof-of-concept study.BMC musculoskeletal disorders · 2021Article
- Safety of Total Knee Arthroplasty in the Treatment of Knee Osteoarthritis and Its Effect on Postoperative Pain and Quality of Life of Patients.Contrast media & molecular imaging · 2021Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
Abstract
objectivesTo examine the effect of occupation on knee osteoarthritis (OA) and total knee replacement (TKR) in working-aged adults.
methodsWe used longitudinal data from the Chingford, Osteoarthritis Initiative (OAI) and Multicentre Osteoarthritis (MOST) studies. Participants with musculoskeletal disorders and/or a history of knee-related surgery were excluded. Participants were followed for up to 19-years (Chingford), 96-months (OAI) and 60-months (MOST) for incident outcomes including radiographic knee OA (RKOA), symptomatic RKOA and TKR. In those with baseline RKOA, progression was defined as the time from RKOA incidence to primary TKR. Occupational job categories and work-place physical activities were assigned to levels of workload. Logistic regression was used to examine the relationship between workload and incident outcomes with survival analyses used to assess progression (reference group: sedentary occupations).
resultsHeavy manual occupations were associated with a 2-fold increased risk (OR: 2.07, 95% CI 1.03 to 4.15) of incident RKOA in the OAI only. Men working in heavy manual occupations in MOST (2.7, 95% CI 1.17 to 6.26) and light manual occupations in OAI (2.00, 95% CI 1.09 to 3.68) had a 2-fold increased risk of incident RKOA. No association was observed among women. Increasing workload was associated with an increased risk of symptomatic RKOA in the OAI and MOST. Light work may be associated with a decreased risk of incident TKR and disease progression.
conclusionHeavy manual work carries an increased risk of incident knee OA; particularly among men. Workload may influence the occurrence of TKR and disease progression.
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Registered trials
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