Evidence map›Paper›PMID 33007513›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022

Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.

Prerana Williamson, James Proudfoot, Armen Gharibans, Lucas Dohil, Robert Newbury, Jacqueline Barsamian, Maheen Hassan, Renee Rawson, David Katzka, Richard Kurten and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Development and dysfunction of structural cells in eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Prerana WilliamsonDepartment of Pediatrics, University of California, San Diego, California; Division of Pediatric Gastroenterology, Rady Children's Hospital, San Diego, California; Rady Children's Hospital, San Diego, California.
James ProudfootAltman Clinical and Translational Research Institute, University of California, San Diego, California.
Armen GharibansRady Children's Hospital, San Diego, California; Department of Surgery, University of Auckland, Auckland, New Zealand; Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Lucas DohilDepartment of Pediatrics, University of California, San Diego, California; Division of Allergy and Immunology, University of California San Diego, San Diego, California.
Robert NewburyDepartment of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California; Department of Pathology, University of California San Diego, San Diego, California.
Jacqueline BarsamianRady Children's Hospital, San Diego, California.
Maheen HassanDepartment of Pediatrics, University of California, San Diego, California; Division of Pediatric Gastroenterology, Rady Children's Hospital, San Diego, California; Rady Children's Hospital, San Diego, California.
Renee RawsonDepartment of Pediatrics, University of California, San Diego, California; Division of Allergy and Immunology, University of California San Diego, San Diego, California.
David KatzkaDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Richard KurtenDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Ranjan DohilDepartment of Pediatrics, University of California, San Diego, California; Division of Pediatric Gastroenterology, Rady Children's Hospital, San Diego, California; Rady Children's Hospital, San Diego, California.
Hayat MousaDepartment of Pediatrics, University of California, San Diego, California; Division of Pediatric Gastroenterology, Rady Children's Hospital, San Diego, California; Rady Children's Hospital, San Diego, California.
Seema AcevesRady Children's Hospital, San Diego, California; Division of Allergy and Immunology, University of California San Diego, San Diego, California; Department of Medicine, University of California San Diego, San Diego, California. Electronic address: saceves@health.ucsd.edu.
University of California San Diego · USUniversity of San Diego · USMayo Clinic · USRady Children's Hospital-San Diego · USUniversity of Arkansas for Medical Sciences · USUniversity of Auckland · NZ

Funding

Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
TWEAK/TNFSF12 and LIGHT/TNFSF14 interactions in allergic esophagitis remodelingR01DK114457 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Seema S Aceves, Ferhat Ay · 2018 to 2026
$4.5M
Mechanisms of tissue damage leading to chronic allergic eosinophilic esophagitisR01AI092135 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACEVES, SEEMA S · 2011 to 2020
$4.4M
Expanding Translational Research in ArkansasU54TR001629 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2017 to 2017
$3.5M
The safety and efficacy of megesterol as part of an outpatient feeding protocol for children with chronic medical conditionsR01HD093933 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DAVIS, ANN M · 2018 to 2023
$2.2M
Mentoring Patient Oriented Research in Allergic Eosinophilic Gastrointestinal DisordersK24AI135034 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACEVES, SEEMA S · 2018 to 2022
$898k
NCATS NIH HHS U54 TR001629NIAID NIH HHS K24 AI135034NIAID NIH HHS R01 AI092135NICHD NIH HHS R01 HD093933NIDDK NIH HHS R01 DK114457NIDDK NIH HHS T32 DK007202
6 · The paper itself

Abstract

BACKGROUND &

aimsEsophageal remodeling in eosinophilic esophagitis (EoE) can lead to esophageal rigidity with eventual luminal compromise and stenoses. Gauging esophageal functional alterations in EoE is challenging. An epithelial marker of functional remodeling would impact EoE management.

methodsEsophageal biopsy specimens from children with and without EoE and primary human esophageal epithelial cells were used for PAI-1 immunohistochemistry, and cell proliferation experiments. PAI-1 immunostaining and basal cell hyperplasia were assessed in the context of concurrently obtained esophageal compliance measures on endoscopic functional lumen imaging probe (EndoFLIP).

resultsEndoFLIPs were performed in 45 children (32 with and 13 without EoE). Epithelial PAI-1 was increased in patients with active EoE versus inactive or control patients (P < .01). Esophageal compliance was lower in EoE patients versus controls, particularly in the proximal esophagus (P < .001). Proximal compliance was the strongest predictor of EoE (AUROC 0.88, 95% CI 0.77, 0.98) with esophageal compliance of less than 2.6%mL/mmHg demonstrating 82% sensitivity and 84% specificity for EoE. PAI-1 inhibition significantly diminished esophageal epithelial cell proliferation, suggesting PAI-1 could trigger basal cell hyperplasia. A composite mid-esophageal BZH + PAI-1 score was the strongest predictor of altered compliance (P = .02, AUROC 0.89 (95% CI 0.80, 0.99).

conclusionsPAI-1 is significantly elevated in pediatric EoE and distinguishes altered compliance in children. PAI-1 may be a novel disease marker and therapeutic target.

Indexed as

Eosinophilic EsophagitisChildEpithelial CellsHumansImmunohistochemistryPlasminogen Activator Inhibitor 1Plasminogen Activator Inhibitor 1Basal ZoneEndoscopic Functional Lumen Imaging ProbeEpitheliumEsophageal RigidityRemodeling

Identifiers

PMID33007513
PMCPMC8007666
OpenAlexW3090644819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.