ArticleOphthalmology. Glaucoma
Association between Obstructive Sleep Apnea and Exfoliation Syndrome: The Utah Project on Exfoliation Syndrome.
Article in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- In Search of Mouse Models for Exfoliation Syndrome.American journal of ophthalmology · 2024Article
- Identification of potential core genes in pseudoexfoliation using bioinformatics analysis and retrospective analysis of 84 patients with this disease.International ophthalmology · 2024Review
- Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review.Journal of clinical medicine · 2024Review
- Changes in peri-ocular anatomy and physiology in pseudoexfoliation syndrome (Review).Experimental and therapeutic medicine · 2021Review
- Summary of Utah Project on Exfoliation Syndrome (UPEXS): using a large database to identify systemic comorbidities.BMJ open ophthalmology · 2021Review
- Head and Neck Region Dermatological Ultraviolet-Related Cancers are Associated with Exfoliation Syndrome in a Clinic-Based Population.Ophthalmology. GlaucomaArticle
- Identifiable Historic and Observable Factors May Predict Progression to Exfoliation Glaucoma in Newly Diagnosed Exfoliation Patients.Ophthalmology. GlaucomaArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeExfoliation syndrome (XFS), the most common recognizable cause of open-angle glaucoma worldwide, is a systemic disorder with genetic predisposition due to variations in lysyl oxidase-like 1 (LOXL1) function, leading to altered elastin matrices in ocular and systemic tissues. Obstructive sleep apnea (OSA) is a highly prevalent disorder also involving elastic tissue dysfunction and is associated with glaucoma. Because of the similarities between the disorders, we sought to uncover any relationship in the prevalence of these diagnoses.
designCase-control, retrospective cohort study.
participantsA cohort of 81 735 patients diagnosed with OSA at ages 50 to 90 years was identified from medical records from 1996 to 2017 in the Utah Population Database. Case subjects were matched to random controls on sex and birth year in a 4:1 ratio.
methodsInternational Classification of Diseases, Ninth Revision (ICD-9) codes or their Tenth Revision equivalent were used to define a diagnosis of OSA (ICD-9 327.23) and a diagnosis of XFS (ICD-9 365.52 and 366.11). Conditional logistic regression odds ratios (ORs) accounting for individual matching on sex and birth year were used to estimate the risk of XFS in patients with OSA. Models included adjustment for race, obesity, tobacco use, hypertension (HTN), atrial fibrillation (AF), and chronic obstructive pulmonary disease (COPD).
main outcome measureWhether patients with OSA have an increased risk of diagnosis of XFS compared with controls without OSA.
resultsThere was an increased risk of an XFS diagnosis in patients with OSA compared with non-OSA controls (OR, 1.27; 95% confidence interval [CI], 1.02-1.59; P = 0.03). In a stratification of patients by HTN diagnosis history, patients with OSA and HTN exhibited an increased risk of XFS compared with non-OSA controls with HTN (OR, 2.67; 95% CI, 2.06-3.46; P < 0.0001).
conclusionsPatients with OSA may be at an increased risk of XFS compared with patients without OSA, particularly in patients with a history of HTN.
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