Evidence map›Paper›PMID 33007434›Full record

ArticleInternational journal of radiation oncology, biology, physics2021

Positron Emission Tomography Imaging of Functional Transforming Growth Factor β (TGFβ) Activity and Benefit of TGFβ Inhibition in Irradiated Intracranial Tumors.

Alba Gonzalez-Junca, Oliver Reiners, Luis D Borrero-Garcia, Denis Beckford-Vera, Ann A Lazar, William Chou, Steve Braunstein, Henry VanBrocklin, Benjamin L Franc, Mary Helen Barcellos-Hoff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
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  7. Molecular Pathways and Mechanisms of TGFβ in Cancer Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
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  10. Review
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  13. Exploring the multifaceted role of TGF-β signaling in diabetic complications.Environmental science and pollution research international · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alba Gonzalez-JuncaDepartment of Radiation Oncology, School of Medicine, University of California, San Francisco, California.
Oliver ReinersDepartment of Radiation Oncology, School of Medicine, University of California, San Francisco, California.
Luis D Borrero-GarciaDepartment of Radiation Oncology, School of Medicine, University of California, San Francisco, California.
Denis Beckford-VeraDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Ann A LazarHelen Diller Family Comprehensive Cancer Center, School of Medicine, University of California, San Francisco, California; Division of Oral Epidemiology, School of Dentistry, University of California, San Francisco, California; Division of Biostatistics, School of Medicine, University of California, San Francisco, California.
William ChouDepartment of Radiation Oncology, School of Medicine, University of California, San Francisco, California.
Steve BraunsteinDepartment of Radiation Oncology, School of Medicine, University of California, San Francisco, California.
Henry VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Benjamin L FrancDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California; Division of Oral Epidemiology, School of Dentistry, University of California, San Francisco, California; Department of Radiology, School of Medicine, Stanford University, Palo Alto, California.
Mary Helen Barcellos-HoffDepartment of Radiation Oncology, School of Medicine, University of California, San Francisco, California; Helen Diller Family Comprehensive Cancer Center, School of Medicine, University of California, San Francisco, California. Electronic address: maryhelen.barcellos-hoff@ucsf.edu.
University of California, San Francisco · USStanford University · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Reorienting the Glioblastoma Microenvironment to Respond to ImmunotherapyR01NS109911 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARCELLOS-HOFF, MARY HELEN, WEAVER, VALERIE MARIE · 2019 to 2023
$2.9M
NINDS NIH HHS R01 NS109911
6 · The paper itself

Abstract

purposeTransforming growth factor β (TGFβ) promotes cell survival by endorsing DNA damage repair and mediates an immunosuppressive tumor microenvironment. Thus, TGFβ activation in response to radiation therapy is potentially targetable because it opposes therapeutic control. Strategies to assess this potential in the clinic are needed. METHODS AND MATERIALS: We evaluated positron emission tomography (PET) to image

results

conclusionsThis study demonstrates that

Indexed as

Positron-Emission TomographyAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBrain NeoplasmsCell Line, TumorCell Transformation, NeoplasticFemaleHumansKaplan-Meier EstimateMaleMiceTransforming Growth Factor betaAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedfresolimumabTransforming Growth Factor beta

Identifiers

PMID33007434
PMCPMC7856163
OpenAlexW3089833372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.