Evidence map›Paper›PMID 33007256›Full record

ArticleMolecular cell2020

Transmitting the Signal: Structure of the β1-Adrenergic Receptor-Gs Protein Complex.

Shubhi Pandey, Shirsha Saha, Arun K Shukla

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Feeling at home: Structure of the NTSR1-GNature structural & molecular biology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Shubhi PandeyDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Shirsha SahaDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Arun K ShuklaDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. Electronic address: arshukla@iitk.ac.in.

Funding

DBT-Wellcome Trust India Alliance IA/S/20/1/504916
6 · The paper itself

Abstract

In this issue of Molecular Cell, Su et al. (2020) report a cryo-EM structure of the β1-adrenergic receptor (β1AR) in complex with a heterotrimeric Gs protein, which offers novel insights into receptor activation and provides a structural framework to better understand the transducer-coupling mechanism for adrenergic receptors.

Indexed as

Receptors, AdrenergicSignal TransductionIsoproterenolIsoproterenolReceptors, Adrenergic

Identifiers

PMID33007256
PMCPMC7614521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.