Evidence map›Paper›PMID 33007238›Full record

ReviewCell stem cell2020

Tissue Stem Cells: Architects of Their Niches.

Elaine Fuchs, Helen M Blau

Abstract readReview
In one paragraph

Review in Cell stem cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed.

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  9. A Myocyte-Enriched Long Non-Coding RNA NRMLncR Enhances Myogenesis in Mouse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elaine FuchsRobin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: fuchslb@rockefeller.edu.
Helen M BlauBaxter Foundation Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: hblau@stanford.edu.

Funding

VITAMIN A AND KERATINIZATION IN HUMAN EPITHELIAL CELLSR01AR031737 · NIAMS · UNIVERSITY OF CHICAGO · PI ELAINE FUCHS · 1986 to 2026
$16.6M
GENE EXPRESSION AND DIFFERENTIATION IN HUMAN EPIDERMISR37AR027883 · NIAMS · UNIVERSITY OF CHICAGO · PI ELAINE FUCHS · 1994 to 2026
$13.3M
Skin Stem Cells: Purification and CharacterizationR01AR050452 · NIAMS · ROCKEFELLER UNIVERSITY · PI ELAINE FUCHS · 2004 to 2026
$8.6M
GENE EXPRESSION &DIFFERENTIATION IN HUMAN EPIDERMISR01AR027883 · NIAMS · UNIVERSITY OF CHICAGO · PI FUCHS, ELAINE · 1986 to 2022
$7.6M
Stem Cells for Brain and BrawnR01AG020961 · NIA · STANFORD UNIVERSITY · PI BLAU, HELEN M · 2002 to 2019
$5.0M
Learning Regulatory Drivers of Chromatin and Expression Dynamics during Nuclear ReprogrammingR01HG009674 · NHGRI · STANFORD UNIVERSITY · PI BLAU, HELEN M, KUNDAJE, ANSHUL · 2017 to 2019
$2.1M
Howard Hughes Medical InstituteNHGRI NIH HHS R01 HG009674NIAMS NIH HHS R01 AR027883NIAMS NIH HHS R01 AR031737NIAMS NIH HHS R01 AR050452NIAMS NIH HHS R37 AR027883NIA NIH HHS R01 AG020961
6 · The paper itself

Abstract

Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation in tissue architecture and regenerative demands, SCs often follow similar paradigms in communicating with their microenvironmental "niche" to transition between quiescent and regenerative states. Here we use skin epithelium and skeletal muscle-among the most highly-stressed tissues in our body-to highlight similarities and differences in niche constituents and how SCs mediate natural tissue rejuvenation and perform regenerative acts prompted by injuries. We discuss how these communication networks break down during aging and how understanding tissue SCs has led to major advances in regenerative medicine.

Indexed as

Regenerative MedicineStem CellsMuscle, SkeletalRejuvenation

Identifiers

PMID33007238
PMCPMC7861346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.