Evidence map›Paper›PMID 33007184›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2021

Prognostic impact of paraneoplastic syndromes on patients with non-metastatic renal cell carcinoma undergoing surgery: Results from Canadian Kidney Cancer information system.

Ryan Sun, Rodney H Breau, Ranjeeta Mallick, Simon Tanguay, Frederic Pouliot, Anil Kapoor, Luke T Lavallée, Antonio Finelli, Alan I So, Ricardo A Rendon and 9 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 1 country.

Ryan SunDepartment of Surgery, University of Manitoba, Winnipeg, MB, Canada.
Rodney H BreauDivision of Urology, University of Ottawa, Ottawa, ON, Canada.
Ranjeeta MallickDivision of Urology, University of Ottawa, Ottawa, ON, Canada.
Simon TanguayDivision of Urology, McGill University, Montreal, QC, Canada.
Frederic PouliotDivision of Urology, Department of Surgery, Université Laval, Quebec City, QC, Canada.
Anil KapoorDivision of Urology, McMaster Institute of Urology, Hamilton, ON, Canada.
Luke T LavalléeDivision of Urology, University of Ottawa, Ottawa, ON, Canada.
Antonio FinelliDivision of Urology, University of Toronto, Toronto, ON, Canada.
Alan I SoDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Ricardo A RendonDepartment of Medicine and Urology, Dalhousie University, Halifax, NS, Canada.
Adrian S FaireyDivision of Urology, University of Alberta, Edmonton, AB, Canada.
Jean-Baptiste LattoufDepartment of Surgery, Université de Montréal, Montreal, QC, Canada.
Jun KawakamiSouthern Alberta Institute of Urology, Calgary, AB, Canada.
Bimal BhindiSouthern Alberta Institute of Urology, Calgary, AB, Canada.
Naveen S BasappaDepartment of Oncology, University of Alberta, Edmonton, AB, Canada.
Lori A WoodDepartment of Medicine and Urology, Dalhousie University, Halifax, NS, Canada.
Georg A BjarnasonDivision of Medical Oncology/Hematology, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
Daniel Y C HengTom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
Rahul K BansalDepartment of Surgery, University of Manitoba, Winnipeg, MB, Canada.
University of Ottawa · CADalhousie University · CAUniversity of Alberta · CAUniversity of Manitoba · CAMcGill University · CASunnybrook Health Science Centre · CAUniversité de Montréal · CAUniversité Laval · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe impact of paraneoplastic syndromes (PNS) on survival in patients with renal cell carcinoma (RCC) is uncertain. This study was conducted to analyze the association of PNS with recurrence and survival of patients with non-metastatic RCC undergoing nephrectomy.

methodsThe Canadian Kidney Cancer information system is a multi-institutional cohort of patients started in January 2011. Patients with nephrectomy for non-metastatic RCC were identified. PNS included anemia, polycythemia, hypercalcemia, and weight loss. Associations between PNS and recurrence or death were assessed using Kaplan-Meier curves and multivariable analysis.

resultsOf 4337 patients, 1314 (30.3%) had evidence of one or more PNS. Patients with PNS were older, had higher comorbidity, and had more advanced clinical and pathological tumor characteristics as compared to patients without PNS (all p<0.05). Kaplan-Meier five-year estimated recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were significantly worse in patients with PNS (63.7%, 84.3%, and 79.6%, respectively, for patients with PNS vs. 73.9%, 90.8%, and 90.1%, respectively, for patients without PNS, all p<0.005). On univariable analysis, presence of PNS increased risk of recurrence (hazard ratio [HR] 1.67, 95% confidence interval [CI] 1.48-1.90, p<0.0001) and cancer-related death (HR 1.85, 95% CI 1.34-2.54, p=0.0002). Adjusting for known prognostic factors, PNS was not associated with recurrence or survival.

conclusionsIn non-metastatic RCC patients undergoing surgery, presence of PNS is associated with older age, higher Charlson comorbidity index score, advanced tumor stage, and aggressive tumor histology. Following surgery, baseline PNS is not strongly independently associated with recurrence or death.

Identifiers

PMID33007184
PMCPMC8021432
OpenAlexW3090166067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.