ArticlePloS one2020
Occurrence of Brucella ceti in striped dolphins from Italian Seas.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Brucellosis in Marine Mammals: Meta-Analysis of Prevalence, Infection Patterns, Host Specificity and Zoonotic Potential.Veterinary medicine and science · 2025Pooled it
- Towards Integrated Surveillance of Marine Brucellosis: Diagnostic and Phylogenetic Assessment ofTransboundary and emerging diseases · 2026Article
- Post Mortem Findings of Cetaceans Stranded Along the Campania Coast from 2016 to 2022.Animals : an open access journal from MDPI · 2025Article
- Article
- Serological Diagnosis ofPathogens (Basel, Switzerland) · 2025Article
- Anthropic Pressure on Cetaceans Stranded Along the Ligurian Coast Within the Pelagos Sanctuary: A Case Series.Animals : an open access journal from MDPI · 2024Article
- Pathogen Prevalence in Cetaceans Stranded along the Italian Coastline between 2015 and 2020.Pathogens (Basel, Switzerland) · 2024Article
- Serological Investigation forAnimals : an open access journal from MDPI · 2024Article
- The First Report ofAnimals : an open access journal from MDPI · 2024Article
- [Zoonotic potential of brucellosis in marine mammals].Medecine tropicale et sante internationale · 2024Review
- Combination ofFrontiers in microbiology · 2024Article
- New insights into the pathogenesis and transmission ofMicrobiology spectrum · 2023Article
- Article
- Histopathologic and immunohistochemical findings in the placentas and fetuses of domestic swine naturally infected withJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Article
- Viral skin diseases in odontocete cetaceans: gross, histopathological, and molecular characterization of selected pathogens.Frontiers in veterinary science · 2023Article
- Spatio-Temporal Distribution of Brucellosis in European Terrestrial and Marine Wildlife Species and Its Regional Implications.Microorganisms · 2022Review
- Brucella ceti and Brucella pinnipedialis genome characterization unveils genetic features that highlight their zoonotic potential.MicrobiologyOpen · 2022Article
- Article
- Cellular Prion Protein Expression in the Brain Tissue fromAnimals : an open access journal from MDPI · 2022Article
- Neuropathological Characterization of Dolphin Morbillivirus Infection in Cetaceans Stranded in Italy.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucella ceti infections have been increasingly reported in cetaceans, although a very limited characterization of Mediterranean Brucella spp. isolates has been previously reported and relatively few data exist about brucellosis among cetaceans in Italy. To address this gap, we studied 8 cases of B. ceti infection in striped dolphins (Stenella coeruleoalba) stranded along the Italian coastline from 2012 to 2018, investigated thanks to the Italian surveillance activity on stranded cetaceans. We focused on cases of stranding in eastern and western Italian seas, occurred along the Apulia (N = 6), Liguria (N = 1) and Calabria (N = 1) coastlines, through the analysis of gross and microscopic findings, the results of microbiological, biomolecular and serological investigations, as well as the detection of other relevant pathogens. The comparative genomic analysis used whole genome sequences of B. ceti from Italy paired with the publicly available complete genomes. Pathological changes consistent with B. ceti infection were detected in the central nervous system of 7 animals, showing non-suppurative meningoencephalitis. In 4 cases severe coinfections were detected, mostly involving Dolphin Morbillivirus (DMV). The severity of B. ceti-associated lesions supports the role of this microbial agent as a primary neurotropic pathogen for striped dolphins. We classified the 8 isolates into the common sequence type 26 (ST-26). Whole genome SNP analysis showed that the strains from Italy clustered into two genetically distinct clades. The first clade comprised exclusively the isolates from Ionian and Adriatic Seas, while the second one included the strain from the Ligurian Sea and those from the Catalonian coast. Plotting these clades onto the geographic map suggests a link between their phylogeny and topographical distribution. These results represent the first extensive characterization of B. ceti isolated from Italian waters reported to date and show the usefulness of WGS for understanding of the evolution of this emerging pathogen.
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