ArticlePloS one2020
Acute severe asthma requiring invasive mechanical ventilation in the era of modern resuscitation techniques: A 10-year bicentric retrospective study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Asthma exacerbation requiring ventilatory support in adults: a 10-year retrospective multicentre cohort study - the ESAVA study.BMJ open respiratory research · 2026Article
- Predicting 30-day in-hospital mortality in ICU asthma patients: a retrospective machine learning study with external validation.BMC pulmonary medicine · 2025Article
- Life-threating Asthma Exacerbation Successfully Treated with Benralizumab.Internal medicine (Tokyo, Japan) · 2025Article
- The Determinants of Eosinophilia in Patients With Severe Asthma.Journal of clinical medicine research · 2024Review
- Plumbagin alleviates obesity-related asthma: Targeting inflammation, oxidative stress, and the AMPK pathway.Immunity, inflammation and disease · 2023Article
- Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure.Chest · 2023Observational
- Caring for the Unvaccinated.Annals of the American Thoracic Society · 2022Article
- Treating Acute Severe Eosinophilic Asthma with IL-5 Inhibitors in ICU.Case reports in pulmonology · 2022Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with acute severe asthma (ASA) may in rare cases require invasive mechanical ventilation (IMV). However, recent data on this issue are lacking. MATERIALS AND
methodsIn this retrospective and bicentric study conducted on a 10 year period, we investigate the in-hospital mortality in patients with ASA requiring IMV. We compare this mortality to that of patients with other types of respiratory distress using a standardized mortality ratio (SMR) model.
resultsEighty-one episodes of ASA requiring IMV were evaluated. Factors significantly associated with in-hospital mortality were cardiac arrest on day of admission, cardiac arrest as the reason for intubation, absence of decompensation risk factors, need for renal replacement therapy on day of admission, and intubation in pre-hospital setting. Non-survivors had higher SAPS II, SOFA, creatinine and lactate levels as well as lower blood pressure, pH, and HCO3 on day of admission. In-hospital mortality was 15% (n = 12). Compared to a reference population of 2,670 patients, the SMR relative to the SAPS II was very low at 0.48 (95% CI, 0.25-0.84). The only factor independently associated with in-hospital mortality was cardiac arrest on day of admission. In-hospital mortality was 69% in patients with cardiac arrest on day of admission and 4% in others (p < 0.01). Salvage therapies were given to 7 patients, sometimes in combination with each other: ECMO (n = 6), halogenated gas (n = 1) and anti-IL5 antibody (n = 1). Death occurred in only 2 of these 7 patients, both of whom had cardiac arrest on day of admission.
conclusionNowadays, the mortality of patients with ASA requiring IMV is low. Death is due to multi-organ failure, with cardiac arrest on day of admission being the most important risk factor. In patients who did not have cardiac arrest on day of admission the mortality is even lower (4%) which allows an aggressive management.
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