Evidence map›Paper›PMID 33006889›Full record

ArticleJournal of natural products2021

Cytotoxic Naphthoquinone Analogues, Including Heterodimers, and Their Structure Elucidation Using LR-HSQMBC NMR Experiments.

Laura Flores-Bocanegra, Huzefa A Raja, Jeffrey W Bacon, Amanda C Maldonado, Joanna E Burdette, Cedric J Pearce, Nicholas H Oberlies

Abstract read
In one paragraph

Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura Flores-BocanegraDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27412, United States.ORCID 0000-0002-1393-7834
Huzefa A RajaDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27412, United States.ORCID 0000-0002-0824-9463
Jeffrey W BaconDepartment of Chemistry, Boston University, Boston, Massachusetts 02215, United States.
Amanda C MaldonadoDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Joanna E BurdetteDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-7271-6847
Cedric J PearceMycosynthetix, Inc., Hillsborough, North Carolina 27278, United States.
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27412, United States.ORCID 0000-0002-0354-8464

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
NCI NIH HHS P01 CA125066NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Approximately 1700 naphthoquinones have been reported from a range of natural product source materials, but only 283 have been isolated from fungi, fewer than 75 of those were dimers, and only 2 were heterodimers with a head-to-tail linkage. During a search for anticancer leads from fungi, a series of new naphthoquinones (

Indexed as

Antineoplastic AgentsBiological ProductsCell Line, TumorFungiHumansMagnetic Resonance SpectroscopyMolecular StructureNaphthoquinonesSpectrometry, Mass, Electrospray IonizationAntineoplastic AgentsBiological ProductsNaphthoquinones

Identifiers

PMID33006889
PMCPMC8005429

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.